Sodium Nitrite Attenuates Reduced Activity of Vascular Matrix Metalloproteinase-2 and Vascular Hyper-Reactivity and Increased Systolic Blood Pressure Induced by the Placental Ischemia Model of Preeclampsia in Anesthetized Rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Ribeirao Preto (UNAERP)-
Autor(es): dc.contributorStockholm University-
Autor(es): dc.creatorMartins, Laisla Zanetoni-
Autor(es): dc.creatorda Silva, Maria Luiza Santos-
Autor(es): dc.creatorRodrigues, Serginara David-
Autor(es): dc.creatorGomes, Sáskia Estela Biasotti-
Autor(es): dc.creatorMolezini, Laura-
Autor(es): dc.creatorRizzi, Elen-
Autor(es): dc.creatorMontenegro, Marcelo Freitas-
Autor(es): dc.creatorDias-Junior, Carlos Alan-
Data de aceite: dc.date.accessioned2025-08-21T21:15:46Z-
Data de disponibilização: dc.date.available2025-08-21T21:15:46Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms241612818-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309461-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309461-
Descrição: dc.descriptionPreeclampsia is a maternal hypertension disorder associated with vascular dysfunction and fetal and placental growth restrictions. Placental ischemia is suggested as the primary trigger of preeclampsia-associated impairments of both endothelium-derived nitric oxide (NO) and the vascular activity of extracellular matrix metalloproteinase-2 (MMP-2). Reduced uteroplacental perfusion pressure (RUPP) is a placental ischemia model of preeclampsia. Reduction of sodium nitrite to NO may occur during ischemic conditions. However, sodium nitrite effects in the RUPP model of preeclampsia have not yet been investigated. Pregnant rats were divided into four groups: normotensive pregnant rats (Norm-Preg), pregnant rats treated with sodium nitrite (Preg + Nitrite), preeclamptic rats (RUPP), and preeclamptic rats treated with sodium nitrite (RUPP + Nitrite). Maternal blood pressure and fetal and placental parameters were recorded. Vascular function, circulating NO metabolites, and the gelatinolytic activity of vascular MMP-2 were also examined. Sodium nitrite attenuates increased blood pressure, prevents fetal and placental weight loss, counteracts vascular hyper-reactivity, and partially restores NO metabolites and MMP-2 activity. In conclusion, sodium nitrite reduction to NO may occur during RUPP-induced placental ischemia, thereby attenuating increased blood pressure, fetal and placental growth restriction, and vascular hyper-reactivity associated with preeclampsia and possibly restoring NO and MMP-2 activity, which underlie the blood pressure-lowering effects.-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionUnit of Biotechnology University of Ribeirao Preto (UNAERP)-
Descrição: dc.descriptionDepartment of Molecular Biosciences The Wenner-Gren Institute Stockholm University-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences Sao Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectmetalloproteinase-2-
Palavras-chave: dc.subjectnitric oxide-
Palavras-chave: dc.subjectplacental ischemia-
Palavras-chave: dc.subjectpreeclampsia-
Palavras-chave: dc.subjectsodium nitrite-
Título: dc.titleSodium Nitrite Attenuates Reduced Activity of Vascular Matrix Metalloproteinase-2 and Vascular Hyper-Reactivity and Increased Systolic Blood Pressure Induced by the Placental Ischemia Model of Preeclampsia in Anesthetized Rats-
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Aparece nas coleções:Repositório Institucional - Unesp

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