Subchronic exposure to nonylphenol ethoxylate (NPE) induces cardiotoxicity and oxidative stress in American bullfrog tadpoles: a mechanistic approach

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Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorGonçalves, Yan Costa-
Autor(es): dc.creatorda Silva, Bruno Hofstatter-
Autor(es): dc.creatorde Godoy, Camila Reis-
Autor(es): dc.creatorRantin, Francisco Tadeu-
Autor(es): dc.creatorKalinin, Ana Lúcia-
Autor(es): dc.creatorMonteiro, Diana Amaral-
Data de aceite: dc.date.accessioned2025-08-21T22:49:40Z-
Data de disponibilização: dc.date.available2025-08-21T22:49:40Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10646-024-02822-3-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309394-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309394-
Descrição: dc.descriptionTropical regions, particularly those with high levels of endemism such as South America, harbor a diverse array of amphibian species. However, these regions often lack specific regulations governing the release of emerging contaminants, including the surfactant nonylphenol ethoxylate (NPE), into water bodies, which can have devastating consequences for these sensitive ecosystems. This study evaluated the sublethal effects of 16-day subchronic exposure to NPE at an environmentally relevant concentration of 30 µg/L on American bullfrog (Lithobates catesbeianus) tadpoles using multiple endpoints, including biometric parameters, antioxidant responses, oxidative stress biomarkers, heart rate, and myocardial contractility. Our results revealed that exposure to NPE elicited a range of harmful effects on tadpoles, including significant reductions in hepatic and ventricular mass, disruptions in antioxidant defenses leading to oxidative stress-mediated damage in cardiac, hepatic, and muscular tissues, and changes in heart function such as negative inotropism and lusitropism, and tachycardia. These sublethal effects could have significant ecological impacts, affecting not only immediate survival but also compromising overall fitness through the reallocation of energy reserves.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Physiological Sciences Federal University of São Carlos (UFSCar), São Paulo-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences – Federal University of São Carlos (UFSCar)/São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences – Federal University of São Carlos (UFSCar)/São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionCNPq: C.R.G fellowships-
Descrição: dc.descriptionCAPES: CAPES-
Descrição: dc.descriptionCNPq: CNPq 301809/2022-4: D.A.M. fellowship of research productivity - PQ-
Descrição: dc.descriptionCAPES: Finance Code 001-
Descrição: dc.descriptionCNPq: PIBIC: B.H.S.-
Descrição: dc.descriptionCAPES: 88887.823179/2023-00 – Y.C.G. fellowship-
Formato: dc.format181-192-
Idioma: dc.languageen-
Relação: dc.relationEcotoxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAmphibian-
Palavras-chave: dc.subjectCardiac function-
Palavras-chave: dc.subjectEmerging contaminant-
Palavras-chave: dc.subjectLithobates catesbeianus-
Palavras-chave: dc.subjectOxidative stress-
Título: dc.titleSubchronic exposure to nonylphenol ethoxylate (NPE) induces cardiotoxicity and oxidative stress in American bullfrog tadpoles: a mechanistic approach-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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