Intraoral Foreign Body-Type Giant Cell Reaction in a Sjögren’s Syndrome Patient: An Immunohistochemical Analysis

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorForero, Brenda Carolina Pattigno-
Autor(es): dc.creatorReyes, Magdalena Raquel Torres-
Autor(es): dc.creatorPosantes, Gabriela Esperanza Maradiaga-
Autor(es): dc.creatorde Almeida, Isabella Victoria-
Autor(es): dc.creatorMartins, Karina Helen-
Autor(es): dc.creatorBufalino, Andreia-
Autor(es): dc.creatorLeón, Jorge Esquiche-
Data de aceite: dc.date.accessioned2025-08-21T15:22:19Z-
Data de disponibilização: dc.date.available2025-08-21T15:22:19Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s12663-024-02376-1-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309376-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309376-
Descrição: dc.descriptionSjögren’s syndrome (SS) is a chronic autoimmune disease characterized by lymphocytic infiltration that mainly affects the salivary and lacrimal glands, causing sicca symptoms. Non-infectious granulomatous inflammation affecting the salivary glands is rare, and it may be caused by duct obstruction associated with mucus extravasation. A 63-year-old female patient, with primary SS diagnosis 19 years ago, was referred presenting a nodular mass on the buccal mucosa 1 week ago. Microscopic analysis revealed focal lymphocytic sialadenitis and an exuberant lymphoplasmacytic infiltrate containing in the central part a foreign body-type giant cell reaction, permeated by numerous residual salivary gland ducts. Polarizing microscopy did not identify foreign material. Grocott-Gomori, acid-fast bacilli and Gram stains were negative. However, periodic acid-Schiff and mucicarmine stains revealed positivity in several multinucleated giant cells (MGC), adjacent macrophages and extracellular environment, consistent com mucus extravasation origin. Immunohistochemical analysis revealed strong positivity for CD68, CD163 and CD11c, highlighting MGC and macrophages, permeated by numerous T cells, B cells and plasma cells, whereas pan-CK and EMA evidenced residual salivary gland ducts. In the current case, mucus extravasation is a probable cause of foreign body-type giant cell reaction, suggesting a possible relationship with immune mechanisms of SS involved in its pathogenesis.-
Descrição: dc.descriptionDepartment of Pediatric Dentistry Ribeirão Preto Dental School University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Pathology School of Dentistry University of Estadual Paulista Júlio de Mesquita Filho (UNESP)-
Descrição: dc.descriptionDepartment of Stomatology Public Oral Health and Forensic Dentistry Ribeirão Preto Dental School (FORP/USP) University of São Paulo, Av Do Café, S/N Campus USP, Ribeirão Preto-
Descrição: dc.descriptionDepartment of Pathology and Forensic Medicine Ribeirão Preto Medical School (FMRP/USP) University of São Paulo-
Descrição: dc.descriptionDepartment of Pathology School of Dentistry University of Estadual Paulista Júlio de Mesquita Filho (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationJournal of Maxillofacial and Oral Surgery-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectFocal lymphocytic sialadenitis-
Palavras-chave: dc.subjectForeign body-type giant cell reaction-
Palavras-chave: dc.subjectNon-infectious granulomatous inflammation-
Palavras-chave: dc.subjectSjögren’s syndrome-
Título: dc.titleIntraoral Foreign Body-Type Giant Cell Reaction in a Sjögren’s Syndrome Patient: An Immunohistochemical Analysis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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