Synthesis of copaiba (Copaifera officinalis) oil nanoemulsion and the potential against Zika virus: An in vitro study

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCentro Metropolitano-
Autor(es): dc.contributorUniversity of Brasilia-
Autor(es): dc.contributorMilitary Institute of Engineering-
Autor(es): dc.creatorCarvalho, Tamara-
Autor(es): dc.creatorLandim, Marcela Guimarães-
Autor(es): dc.creatorLima, Maria Letícia Duarte-
Autor(es): dc.creatorBittar, Cíntia-
Autor(es): dc.creatorde Araújo Oliveira Faria, Beatriz Carvalho-
Autor(es): dc.creatorRahal, Paula-
Autor(es): dc.creatorde Lima, Milena Campelo Freitas-
Autor(es): dc.creatorda Veiga, Valdir Florêncio-
Autor(es): dc.creatorJoanitti, Graziella Anselmo-
Autor(es): dc.creatorCalmon, Marilia Freitas-
Data de aceite: dc.date.accessioned2025-08-21T15:59:04Z-
Data de disponibilização: dc.date.available2025-08-21T15:59:04Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0283817-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309300-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309300-
Descrição: dc.descriptionZika virus (ZIKV) has spread all over the world since its major outbreak in 2015. This infection has been recognized as a major global health issue due to the neurological complications related to ZIKV infection, such as Guillain–Barré Syndrome and Zika virus Congenital Syndrome. Currently, there are no vaccines or specific treatments for ZIKV infection, which makes the development of specific therapies for its treatment very important. Several studies have been developed to analyze the potential of compounds against ZIKV, with the aim of finding new promising treatments. Herein, we evaluate the ability of a copaiba (Copaifera officinalis) oil nanoemulsion (CNE) to inhibit ZIKV. First, the highest non-cytotoxic concentration of 180 μg/mL was chosen since this concentration maintains 80% cell viability up to 96h after treatment with CNE in VERO cells resulted from MTT assay. The intracellular uptake assay was performed, and confirmed the internalization of the nanoemulsion in cells at all times analyzed. VERO cells were infected with ZIKV and simultaneously treated with CNE and the nanoformulation without oil (ENE) at the highest non-toxic concentration. The results evaluated by plaque assay revealed a viral inhibition of 80% for CNE and 70% for ENE. A dose-dependence assay revealed that the CNE treatment demonstrated a dose-dependent response in the viral RNA levels, whereas all ENE tested concentrations exhibited a similar degree of reduction. Taken together, our results suggest CNE as a promising nano-sized platform to be further studied for antiviral treatments.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionInstituto Nacional de Ciência e Tecnologia de Nanobiofarmacêutica-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Biology São Paulo State University UNESP, Rua Cristóvão Colombo-
Descrição: dc.descriptionLaboratory of Bioactive Compounds and Nanobiotechnology (LBCNano) University of Brasilia Centro Metropolitano, Campus Universitário, Ceilândia Sul, Federal District-
Descrição: dc.descriptionPost-Graduation Program in Nanoscience and Nanobiotechnology Institute of Biological Sciences University of Brasilia, Campus Universitário Darcy Ribeiro-
Descrição: dc.descriptionChemistry Section Military Institute of Engineering, Praça Gen. Tibúrcio, Praia Vermelha-
Descrição: dc.descriptionDepartment of Biology São Paulo State University UNESP, Rua Cristóvão Colombo-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2019/07784-3-
Idioma: dc.languageen-
Relação: dc.relationPLoS ONE-
???dc.source???: dc.sourceScopus-
Título: dc.titleSynthesis of copaiba (Copaifera officinalis) oil nanoemulsion and the potential against Zika virus: An in vitro study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.