NMR and X-ray diffraction conformational study of guanidines

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorZampieri, Eduardo Henrique-
Autor(es): dc.creatorRibeiro dos Anjos, Luana-
Autor(es): dc.creatorSantiago, Pedro Henrique de Oliveira-
Autor(es): dc.creatorNascimento, Tainara Rosário da Silva-
Autor(es): dc.creatorEllena, Javier-
Autor(es): dc.creatorGonzález, Eduardo René Pérez-
Data de aceite: dc.date.accessioned2025-08-21T20:49:36Z-
Data de disponibilização: dc.date.available2025-08-21T20:49:36Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-04-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.molstruc.2024.138876-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309275-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309275-
Descrição: dc.descriptionLeishmaniasis is a neglected disease that affects regions such as South Asia, South Africa, and Latin America, less developed regions. The research proposed the conformational study of brominated guanidine compounds with potential antileishmanial activity using Nuclear Magnetic Resonance (NMR) and X-ray diffraction (XRD) techniques. The present study involves the brominated molecules LQOF-G2, LQOF-G30, LQOF-G35 and LQOF-G35-Br. The latter was synthesized by the reaction of LQOF-G35 with NBS under IR irradiation at 120 Watts of potency and dichloromethane as solvent by 12 h of exposition. The obtained results demonstrated the efficiency of the bromination method, since two bromine atoms entered the molecule. Furthermore, NMR analysis showed a conformational change from Z to E when compound LQOF-G35 was brominated to LQOF-G35-Br. This behavior was confirmed by a comparative XRD study of the LQOF-G35 and LQOF-G35-Br compounds. The antileishmanial activity of LQOF-G2 e LQOF-G35 motivated the synthesis of new brominated compounds LQOF-G30 e LQOF-G35-Br.-
Descrição: dc.descriptionFine Organic Chemistry Lab School of Sciences and Technology São Paulo State University (UNESP)-
Descrição: dc.descriptionMultiuser Structural Crystallography Laboratory São Carlos Institute of Physics University of São Paulo (USP)-
Descrição: dc.descriptionFine Organic Chemistry Lab School of Sciences and Technology São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationJournal of Molecular Structure-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBromination-
Palavras-chave: dc.subjectConformation study-
Palavras-chave: dc.subjectGuanidines-
Palavras-chave: dc.subjectNBS-
Palavras-chave: dc.subjectNMR-
Palavras-chave: dc.subjectXRD-
Título: dc.titleNMR and X-ray diffraction conformational study of guanidines-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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