Systemic calcinosis in horses: Pathological and genetic aspects

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal Do Rio Grande Do Sul-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorEquineMed—Clínica Veterinária-
Autor(es): dc.creatorCarvalho Serena, Guilherme-
Autor(es): dc.creatorMarchezan Piva, Manoela-
Autor(es): dc.creatorViezzer Bianchi, Matheus-
Autor(es): dc.creatorFernandes da Fonseca, Helena Carolina-
Autor(es): dc.creatorChitolina Pupin, Rayane-
Autor(es): dc.creatorMartins Basso, Roberta-
Autor(es): dc.creatorSecorun Borges, Alexandre-
Autor(es): dc.creatorMonteiro Nunes, Marcelo-
Autor(es): dc.creatorDriemeier, David-
Autor(es): dc.creatorPanziera, Welden-
Autor(es): dc.creatorOliveira-Filho, José Paes-
Autor(es): dc.creatorGomes, Danilo Carloto-
Autor(es): dc.creatorPavarini, Saulo Petinatti-
Data de aceite: dc.date.accessioned2025-08-21T21:28:50Z-
Data de disponibilização: dc.date.available2025-08-21T21:28:50Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/evj.14464-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309083-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309083-
Descrição: dc.descriptionBackground: In horses, systemic calcinosis is a rare syndrome characterised by muscle lesion associated with the mineralisation of large muscle groups or other organs, in the absence of an alternative cause for the calcification, such as toxic, enzootic or metabolic. Molecular and histopathological aspects of the disease are still poorly elucidated. Objectives: To describe the epidemiological, pathological and molecular aspects of systemic calcinosis in a convenience sample of six horses submitted to necropsy in the Southern and Midwestern regions of Brazil. Study design: Retrospective exploratory study. Methods: Post-mortem necropsy records of six horses with a cause of death compatible with systemic calcinosis, were reviewed followed by histopathology, immunohistochemistry, microbiology and molecular investigation. Results: The affected horses were all Quarter Horses with a mean age of 16.8 months, and an average disease course of 15.5 days. Muscle necrosis and mononuclear infiltration were observed in all animals in association with mineral deposition variably affecting the muscle tissue and/or other organs such as heart, lung and kidney. All tested animals (5/6) showed positive PCR results for the E321G MYH1 gene variant, which encodes the heavy chain of fast-contracting skeletal muscle myosin and is associated with myopathy. Three horses demonstrated positive immunostaining for Streptococcus equi, which is a known trigger for immune responses. Main limitations: The study was limited by the small sample size, molecular evaluation was not completed in one animal due to technical limitations, lack of pre-mortem evaluation of calcium metabolism and lack of accurate descriptions in the necropsy reports of involvement of each muscle individually. Conclusions: In horses, systemic calcinosis syndrome causes immune-mediated muscle lesions in association with calcification of organs and tissues, varying greatly among animals. The E321G MYH1 variant was present in all horses tested for the variant and could be involved in the pathophysiology of systemic calcinosis.-
Descrição: dc.descriptionSetor de Patologia Veterinária Universidade Federal Do Rio Grande Do Sul, RS-
Descrição: dc.descriptionLaboratório de Anatomia Patológica—Faculdade de Medicina Veterinária e Zootecnia Universidade Federal de Mato Grosso do Sul, Mato Grosso do Sul-
Descrição: dc.descriptionDepartamento de Ciências Clínicas Veterinárias Laboratório de Biologia Molecular Universidade Estadual Paulista (Unesp) Faculdade de Medicina Veterinária e Ciência Animal, São Paulo-
Descrição: dc.descriptionEquineMed—Clínica Veterinária, MS-
Descrição: dc.descriptionDepartamento de Ciências Clínicas Veterinárias Laboratório de Biologia Molecular Universidade Estadual Paulista (Unesp) Faculdade de Medicina Veterinária e Ciência Animal, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationEquine Veterinary Journal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectgenetic variant-
Palavras-chave: dc.subjecthorse-
Palavras-chave: dc.subjectmineralisation-
Palavras-chave: dc.subjectmuscle disease-
Palavras-chave: dc.subjectMYH1-
Palavras-chave: dc.subjectStreptococcus equi-
Título: dc.titleSystemic calcinosis in horses: Pathological and genetic aspects-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.