The role of extracellular vesicles in cancer

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorPaulista University-
Autor(es): dc.contributorCentral Unit of Valle del Cauca (UCEVA)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPerez Hurtado, Elizabeth Cristina-
Autor(es): dc.creatorHenao Agudelo, Juan Sebastian-
Autor(es): dc.creatorFoganholi da Silva, Rodrigo Augusto-
Autor(es): dc.creatorViração, Thiago Albuquerque-
Autor(es): dc.creatorFernandes, Célio Junior da Costa-
Data de aceite: dc.date.accessioned2025-08-21T18:52:37Z-
Data de disponibilização: dc.date.available2025-08-21T18:52:37Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/bs.ctm.2024.06.010-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308960-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308960-
Descrição: dc.descriptionExtracellular vesicles (EVs), which include small EVs such as exosomes, play a critical role in intercellular communication and are produced by both cancer and non-cancer cells. Several studies have shown that cancer cells exploit various strategies to regulate the biogenesis, composition, and functions of EVs primarily to promote cancer progression. Given that exosomes originate from major sorting hubs at the limiting membrane of endosomes, they are central to a signaling network that connects external stimuli with intrinsic tumor cell features. Exosomes contain diverse repertoires of molecular cargos, such as proteins, lipids, and nucleic acids, which determine their heterogeneity and functional properties in cancer progression. Therefore, targeting exosome biogenesis will enhance our understanding of tumorigenesis and also promote the discovery of novel approaches for cancer therapy. In this chapter we summarize the machinery of exosome biogenesis and the local, distant, and systemic effects of exosomes released by cancer cells. Furthermore, we explore how these exosomes regulate the anti-tumor immune response and epigenetic mechanisms to sustain cancer progression and their implications in cancer prevention and treatment.-
Descrição: dc.descriptionGraduate Program in Environmental and Experimental Pathology Paulista University, São Paulo-
Descrição: dc.descriptionFaculty of Health Sciences Central Unit of Valle del Cauca (UCEVA), Valle del Cauca-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP), São Paulo-
Formato: dc.format247-285-
Idioma: dc.languageen-
Relação: dc.relationCurrent Topics in Membranes-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCancer progression-
Palavras-chave: dc.subjectCancer therapy-
Palavras-chave: dc.subjectCell communication-
Palavras-chave: dc.subjectEpigenetic modifiers-
Palavras-chave: dc.subjectExosome-
Palavras-chave: dc.subjectImmune surveillance-
Palavras-chave: dc.subjectMicroRNAs-
Palavras-chave: dc.subjectRabs proteins-
Palavras-chave: dc.subjectSmall extracellular vesicles-
Palavras-chave: dc.subjectTumor microenvironment-
Título: dc.titleThe role of extracellular vesicles in cancer-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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