Assessment of prostate tissue remodeling in rats exposed to bisphenol A and the phytoestrogens genistein and indole-3-carbinol during the perinatal period

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Autor(es): dc.contributorUniversidade do Oeste Paulista (UNOESTE)-
Autor(es): dc.contributorHenry Ford Health-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBueno, Éricka Stéphanny Brandão-
Autor(es): dc.creatorNeto, Carlos Domingos Vieira-
Autor(es): dc.creatorRodrigues, Alessandro-
Autor(es): dc.creatorSousa, Thaina Cavalleri-
Autor(es): dc.creatorHinokuma, Karianne Delalibera-
Autor(es): dc.creatorde Aquino, Ariana Musa-
Autor(es): dc.creatorScarano, Wellerson Rodrigo-
Autor(es): dc.creatorBrandt, Joyce Zalotti-
Autor(es): dc.creatorMendes, Leonardo de Oliveira-
Data de aceite: dc.date.accessioned2025-08-21T19:04:43Z-
Data de disponibilização: dc.date.available2025-08-21T19:04:43Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/0103-8478cr20230205-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308881-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308881-
Descrição: dc.descriptionBisphenol A (BPA) is a compound known for its direct action on the prostate. Prostatic morphogenesis is a critical period when interference by any compound could permanently damage the organ. As such, the present study evaluated the morphological aspects resulting from gestational and lactational administration of BPA, indole-3-carbinol (I3C) and genistein (GEN) in prepubescent male rats. Pregnant Sprague Dawley females were allocated into 4 experimental groups and received the following: C: Control (no treatment); B: BPA (10 µg/Kg); BG: BPA+GEN (5 mg/Kg); BI: BPA+I3C (20 mg/Kg) from gestation day (GD) 17 to postnatal day (PND) 21. After euthanasia on PND22, the prostate was collected and processed. When administered alone, BPA reduced the stromal compartment when compared to group C (P = 0.039). This decline was reversed in the groups submitted to GEN (P = 0.019) or I3C (P = 0.017). The groups treated with BPA (P < 0.0001) and the phytoestrogens (P < 0.0001) exhibited decreased epithelial height in relation to the control group. These changes were observed in stereological and morphometric analyses, but not in fractal analysis (P = 0.569). The area occupied by collagen increased in groups treated with BPA (P < 0.0001) and phytoestrogens (P < 0.0001) in relation to controls, while collagen distribution values were higher in all the treated groups (P < 0.0001), according to fractal analysis. Thus, BPA induced prostrate stroma remodeling with no influence from the phytoestrogens, which may affect glandular development and cause histopathological changes in adulthood.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniversidade do Oeste Paulista (UNOESTE), SP-
Descrição: dc.descriptionFaculdade de Ciências da Saúde Universidade do Oeste Paulista (UNOESTE), SP-
Descrição: dc.descriptionHenry Ford Cancer Institute Henry Ford Health-
Descrição: dc.descriptionDepartamento de Biologia Estrutural e Funcional Instituto de Biociências (IBB) Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionDepartamento de Biologia Estrutural e Funcional Instituto de Biociências (IBB) Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionFAPESP: 2012/24935-6-
Idioma: dc.languageen-
Relação: dc.relationCiencia Rural-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectendocrine disruptor-
Palavras-chave: dc.subjectenvironmental exposure-
Palavras-chave: dc.subjectphytonutrients-
Palavras-chave: dc.subjectprostate-
Título: dc.titleAssessment of prostate tissue remodeling in rats exposed to bisphenol A and the phytoestrogens genistein and indole-3-carbinol during the perinatal period-
Título: dc.titleAvaliação da remodelação tecidual prostática em ratos expostos ao bisfenol A e aos fitoestrógenos genisteína e indol-3-carbinol durante o período perinatal-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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