Synthesis, Characterization, and Cytotoxicity Evaluation of Chlorambucil-Functionalized Mesoporous Silica Nanoparticles

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Mato Grosso do Sul-
Autor(es): dc.contributorUniversity of Brasilia-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Grande Dourados-
Autor(es): dc.creatorKarnopp, Juliana Camila Fischer-
Autor(es): dc.creatorJorge, Juliana-
Autor(es): dc.creatorda Silva, Jaqueline Rodrigues-
Autor(es): dc.creatorBoldo, Diego-
Autor(es): dc.creatorDel Pino Santos, Kristiane Fanti-
Autor(es): dc.creatorDuarte, Adriana Pereira-
Autor(es): dc.creatorde Castro, Gustavo Rocha-
Autor(es): dc.creatorde Azevedo, Ricardo Bentes-
Autor(es): dc.creatorPrada, Ariadna Lafourcade-
Autor(es): dc.creatorAmado, Jesús Rafael Rodríguez-
Autor(es): dc.creatorMartines, Marco Antonio Utrera-
Data de aceite: dc.date.accessioned2025-08-21T15:56:43Z-
Data de disponibilização: dc.date.available2025-08-21T15:56:43Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/pharmaceutics16081086-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308862-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308862-
Descrição: dc.descriptionThis study describes the synthesis and characterization of chlorambucil (CLB)-functionalized mesoporous silica nanoparticles (MSNs) for potential application in cancer therapy. The nanoparticles were designed with a diameter between 20 and 50 nm to optimize cellular uptake and avoid rapid clearance from the bloodstream. The synthesis method involved modifying a previously reported technique to reduce particle size. Successful functionalization with CLB was confirmed through various techniques, including Fourier transform infrared spectroscopy (FTIR) and elemental analysis. The cytotoxicity of the CLB-functionalized nanoparticles (MSN@NH2-CLB) was evaluated against human lung adenocarcinoma cells (A549) and colon carcinoma cells (CT26WT). The results suggest significantly higher cytotoxicity of MSN@NH2-CLB compared to unbound CLB, with improved selectivity towards cancer cells over normal cells. This suggests that MSN@NH2-CLB holds promise as a drug delivery system for targeted cancer therapy.-
Descrição: dc.descriptionUniversidade Federal de Mato Grosso do Sul-
Descrição: dc.descriptionPostgraduate Program in Chemistry Chemistry Institute Federal University of Mato Grosso do Sul, Campo Grande, MS-
Descrição: dc.descriptionPostgraduate Program in Nanoscience and Nanotechnology Biological Science Institute University of Brasilia, DF-
Descrição: dc.descriptionPostgraduate Program in Environmental Biotechnology Bioscience Institute Sao Paulo State University, SP-
Descrição: dc.descriptionPostgraduate Program in Biotechnology Faculty of Pharmacy Food and Nutrition Federal University of Mato Grosso do Sul, Campo Grande, MS-
Descrição: dc.descriptionPostgraduate Program in Health Sciences Faculty of Health Sciences Federal University of Grande Dourados, MS-
Descrição: dc.descriptionPostgraduate Program in Environmental Biotechnology Bioscience Institute Sao Paulo State University, SP-
Idioma: dc.languageen-
Relação: dc.relationPharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcancer-
Palavras-chave: dc.subjectchlorambucil-
Palavras-chave: dc.subjectcytotoxicity-
Palavras-chave: dc.subjectdrug delivery-
Palavras-chave: dc.subjectmesoporous silica-
Palavras-chave: dc.subjectnanocarriers-
Palavras-chave: dc.subjecttargeted therapy-
Título: dc.titleSynthesis, Characterization, and Cytotoxicity Evaluation of Chlorambucil-Functionalized Mesoporous Silica Nanoparticles-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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