Does chlorhexidine reduce the incidence of ventilator-associated pneumonia in ICU patients? A systematic review and meta-analysis

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Ribeirão Preto (UNAERP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUnisagrado: Centro Universitário Sagrado Coração-
Autor(es): dc.creatorCruz, J. C.-
Autor(es): dc.creatorMartins, C. K.-
Autor(es): dc.creatorPiassi, J. E.V.-
Autor(es): dc.creatorGarcia Júnior, I. R.-
Autor(es): dc.creatorSantiago Junior, J. F.-
Autor(es): dc.creatorFaverani, L. P.-
Data de aceite: dc.date.accessioned2025-08-21T21:41:40Z-
Data de disponibilização: dc.date.available2025-08-21T21:41:40Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.medin.2022.10.002-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308818-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308818-
Descrição: dc.descriptionObjective: This study aimed to investigate chlorhexidine's efficacy in preventing ventilator-associated pneumonia (VAP). Design: A systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Settings: The data were obtained from Pubmed, Cochrane Library, and EMBASE. Patients or participants: Only mechanically ventilated patients for at least 48 h were included. Interventions: Randomized clinical trials applying any dosage form of chlorhexidine were eligible. Main variables of interest: The relative risk (RR) of the VAP incidence and all-cause mortality was assessed using the random-effects model. The mean difference in days of mechanical ventilation duration and intensive care unit (ICU) length of stay were also appraised. Results: Ten studies involving 1233 patients were included in the meta-analysis. The oral application of CHX reduced the incidence of VAP (RR, 0.73 [95% CI, 0.55, 0.97]) and did not show an increase in all-cause mortality (RR, 1.13 [95% CI, 0.96, 1.32]). Conclusions: CHX proved effective to prevent VAP. However, a conclusion on mortality rates could not be drawn because the quality of the evidence was very low for this outcome.-
Descrição: dc.descriptionUniversity of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Medicine University of Ribeirão Preto (UNAERP)-
Descrição: dc.descriptionDivision of Oral and Maxillofacial Surgery Department of Diagnosis and Surgery São Paulo State University (UNESP) School of Dentistry, São Paulo-
Descrição: dc.descriptionDepartment of Health Sciences. Dentistry Course Unisagrado: Centro Universitário Sagrado Coração, SP-
Descrição: dc.descriptionDivision of Oral and Maxillofacial Surgery Department of Diagnosis and Surgery São Paulo State University (UNESP) School of Dentistry, São Paulo-
Formato: dc.format437-444-
Idioma: dc.languageen-
Idioma: dc.languagees-
Relação: dc.relationMedicina Intensiva-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntimicrobial agents-
Palavras-chave: dc.subjectChlorhexidine-
Palavras-chave: dc.subjectMeta-analysis-
Palavras-chave: dc.subjectVentilator-associated pneumonia-
Título: dc.titleDoes chlorhexidine reduce the incidence of ventilator-associated pneumonia in ICU patients? A systematic review and meta-analysis-
Título: dc.title¿El cuidado bucal de rutina con clorhexidina reduce la incidencia de neumonía asociada al ventilador en pacientes de la UCI? Una revisión sistemática y metanálisis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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