Impact of Wine Polyphenols on the Inflammatory Profile of Induced Apical Periodontitis in Rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Paraíba-
Autor(es): dc.contributorFederal Institute of Sertão Pernanbucano-
Autor(es): dc.contributorUniversity of Toronto-
Autor(es): dc.creatorRicci, Rafaela-
Autor(es): dc.creatorde Moura Pereira, Bharbara-
Autor(es): dc.creatorAlvarado, Julissa Denisse Arguello-
Autor(es): dc.creatorde Oliveira Sales-Junior, Romulo-
Autor(es): dc.creatorda Silva Machado, Nathália Evelyn-
Autor(es): dc.creatordos Santos, Doany Cevada-
Autor(es): dc.creatorPederro, Felipe Haddad Martim-
Autor(es): dc.creatorMagnani, Marciane-
Autor(es): dc.creatorLima, Marcos dos Santos-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorCintra, Luciano Tavares Ângelo-
Autor(es): dc.creatorKishen, Anil-
Autor(es): dc.creatorGomes-Filho, João Eduardo-
Data de aceite: dc.date.accessioned2025-08-21T15:26:32Z-
Data de disponibilização: dc.date.available2025-08-21T15:26:32Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.joen.2025.01.023-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308804-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308804-
Descrição: dc.descriptionIntroduction: This study evaluated the impact of dealcoholized red wine polyphenols on the inflammation and lesion volume associated with apical periodontitis (AP) in rats. Methods: Thirty-two Wistar rats receiving AP induction were arranged as follows: Control Group, Dealcoholized Red Wine Group (DRW), Red Wine Group, and Alcohol Group (ALC). Solutions were administered daily in a volume of 4.28 mL/kg via gavage for 45 days. Mandibles and maxillae were removed for histologic, immunohistochemical (IL-1β, IL-10, tumor necrosis factor-alpha, receptor activator of nuclear factor κB ligand, osteoprotegerin [OPG], and tartrate-resistant acid phosphatase), and micro-computed tomography analyses of the AP site. A statistical analysis was performed with a significance level of 5%. Results: Inflammation and TRAP-positive cell count were similar for DRW and Red Wine Group, but lower when compared to Control Group and ALC (P < .001). The immunohistochemical expression of OPG was higher for DRW than for ALC (P < .05). A larger lesion volume was observed in ALC compared to other groups (P < .001). Conclusions: Prophylactic administration of dealcoholized red wine significantly reduced inflammation, decreased the number of TRAP-positive cells, enhanced OPG expression, and reduced lesion volume compared to water and alcohol solutions.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), Sao Paulo-
Descrição: dc.descriptionDepartment of Food Engineering Technology Center Federal University of Paraíba, Paraíba-
Descrição: dc.descriptionDepartment of Food Technology Federal Institute of Sertão Pernanbucano, Pernanbuco-
Descrição: dc.descriptionDepartment of Basic Science School of Dentistry São Paulo State University (UNESP), Sao Paulo-
Descrição: dc.descriptionDepartment of Dentistry Faculty of Dentistry University of Toronto-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), Sao Paulo-
Descrição: dc.descriptionDepartment of Basic Science School of Dentistry São Paulo State University (UNESP), Sao Paulo-
Idioma: dc.languageen-
Relação: dc.relationJournal of Endodontics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectApical periodontitis-
Palavras-chave: dc.subjectbone remodeling-
Palavras-chave: dc.subjectdealcoholized red wine-
Palavras-chave: dc.subjectpolyphenols-
Palavras-chave: dc.subjectwine-
Título: dc.titleImpact of Wine Polyphenols on the Inflammatory Profile of Induced Apical Periodontitis in Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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