Assessing diapocynin's different effects on osteosarcoma and breast cancer cells: An in vitro study

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorSanford Burnham Prebys Medical Discovery Institute-
Autor(es): dc.contributorInstitute for Research in Immunology and Cancer. Université de Montréal-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSantos, Fernanda Cesar dos-
Autor(es): dc.creatorMochetti, Matheus Menão-
Autor(es): dc.creatorTokuhara, Cíntia Kazuko-
Autor(es): dc.creatorPessoa, Adriano de Souza-
Autor(es): dc.creatorInacio, Kelly Karina-
Autor(es): dc.creatorSanches, Mariana Liessa Rovis-
Autor(es): dc.creatorXimenes, Valdecir Farias-
Autor(es): dc.creatorOliveira, Rodrigo Cardoso de-
Data de aceite: dc.date.accessioned2025-08-21T18:41:24Z-
Data de disponibilização: dc.date.available2025-08-21T18:41:24Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.tice.2025.102741-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308766-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308766-
Descrição: dc.descriptionOsteosarcoma is the most common primary bone cancer, accounting for approximately 5 % of new cancer cases globally. In contrast, breast cancer remains the most prevalent malignancy and a leading cause of cancer-related mortality among women. Given the limitations of current therapies, novel treatment strategies are urgently needed. This study evaluates the effects of diapocynin, a derivative of apocynin, on osteosarcoma (UMR-106) and breast cancer (MDA-MB-231) cell lines. Our results demonstrate a dose-dependent cytotoxicity of diapocynin in both cell types, with UMR-106 cells showing higher sensitivity than MDA-MB-231 cells. Notably, treatment with diapocynin induced significant morphological changes in both cell lines, and both IC25 and IC50 concentrations effectively inhibited cell migration, particularly in osteosarcoma cells. However, no significant changes were detected in matrix metalloproteinases −2 and −9 activity following treatment, suggesting that diapocynin may exert its effects through alternative pathways. These results highlight diapocynin as a promising candidate for cancer therapy, warranting further investigation into its mechanisms of action and potential clinical applications.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionBauru Medical School University of São Paulo, SP-
Descrição: dc.descriptionDepartment of Biological Science Bauru School of Dentistry University of São Paulo, SP-
Descrição: dc.descriptionHuman Genetics Program Sanford Burnham Prebys Medical Discovery Institute, La Jolla-
Descrição: dc.descriptionInstitute for Research in Immunology and Cancer. Université de Montréal-
Descrição: dc.descriptionHospital for Rehabilitation of Craniofacial Anomalies University of São Paulo, SP-
Descrição: dc.descriptionDepartment of Chemistry. Faculty of Science São Paulo State University, SP-
Descrição: dc.descriptionDepartment of Chemistry. Faculty of Science São Paulo State University, SP-
Descrição: dc.descriptionFAPESP: 2018/12607–0-
Descrição: dc.descriptionFAPESP: 2020/02160–9-
Descrição: dc.descriptionCNPq: 2021–358-
Descrição: dc.descriptionCNPq: 308897/2021–8-
Idioma: dc.languageen-
Relação: dc.relationTissue and Cell-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBreast cancer cell-
Palavras-chave: dc.subjectDiapocynin-
Palavras-chave: dc.subjectOsteosarcoma-
Título: dc.titleAssessing diapocynin's different effects on osteosarcoma and breast cancer cells: An in vitro study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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