Genotyping and drug susceptibility profiling of Prototheca sp. strains isolated from cases of protothecosis in dogs

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Autor(es): dc.contributorUniversity of Warsaw-
Autor(es): dc.contributorIstituto Zooprofilattico Sperimentale delle Venezie-
Autor(es): dc.contributorPontifical Catholic University of Paraná-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFreie Universitaet Berlin-
Autor(es): dc.contributorNihon University School of Veterinary Medicine-
Autor(es): dc.contributorThe University of Sydney-
Autor(es): dc.creatorProskurnicka, Angelika-
Autor(es): dc.creatorIskra, Mateusz-
Autor(es): dc.creatorWronka, Sylwia-
Autor(es): dc.creatorBakuła, Zofia-
Autor(es): dc.creatorDanesi, Patrizia-
Autor(es): dc.creatorde Farias, Marconi Rodrigues-
Autor(es): dc.creatorRamos Portilho, Fábio Vinícius-
Autor(es): dc.creatorGarcia Ribeiro, Márcio-
Autor(es): dc.creatorRösler, Uwe-
Autor(es): dc.creatorKano, Rui-
Autor(es): dc.creatorMalik, Richard-
Autor(es): dc.creatorJagielski, Tomasz-
Data de aceite: dc.date.accessioned2025-08-21T16:26:22Z-
Data de disponibilização: dc.date.available2025-08-21T16:26:22Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/jvim.17173-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308715-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308715-
Descrição: dc.descriptionBackground: Protothecosis in dogs is a rare, yet emerging disease, distinguished by its often-aggressive clinical course and high fatality rate. Our study was conducted to enhance treatment protocols for affected dogs by better understanding the genetic diversity and drug resistance patterns of Prototheca species. Objectives: To identify species and drug susceptibility profiles of an international collection of 28 Prototheca strains isolated from cases of protothecosis in dogs. Animals: None. Methods: Retrospective study. Species-level identification was made for isolates from 28 dogs in 6 countries by molecular typing with the partial cytb gene as a marker. For the determination of minimum inhibitory concentrations (MICs) and minimum algicidal concentrations (MACs), the Clinical Laboratory Standards Institute (CLSI) protocol (M27-A3) was used. Results: Prototheca bovis was the most prevalent species, accounting for 75% (21/28) of the cases, followed by P. wickerhamii (18%; 5/28) and P. ciferrii (7%; 2/28). Of the 6 drugs tested, efinaconazole (EFZ) was the most potent in vitro, with its median MIC and MAC values equal to 0.125 mg/L. The lowest activity was found for fluconazole (FLU), with MIC and MAC medians of 48 mg/L and 64 mg/L, respectively. Conclusions and Clinical Importance: Our study identifies P. bovis as the species that most frequently causes protothecosis in dogs, which suggests the possibility of cross-species infection from other animals, especially cows. Additionally, it indicates that EFZ could be used in the treatment of infection in the colon.-
Descrição: dc.descriptionDepartment of Medical Microbiology Institute of Microbiology Faculty of Biology University of Warsaw-
Descrição: dc.descriptionIstituto Zooprofilattico Sperimentale delle Venezie-
Descrição: dc.descriptionPostgraduate Program in Animal Science Pontifical Catholic University of Paraná-
Descrição: dc.descriptionDepartment of Animal Production and Preventive Veterinary Medicine São Paulo State University-
Descrição: dc.descriptionInstitute for Animal Hygiene and Environmental Health Freie Universitaet Berlin-
Descrição: dc.descriptionDepartment of Veterinary Dermatology Nihon University School of Veterinary Medicine, Kanagawa-
Descrição: dc.descriptionCentre for Veterinary Education Sydney School of Veterinary Science The University of Sydney-
Descrição: dc.descriptionDepartment of Animal Production and Preventive Veterinary Medicine São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationJournal of Veterinary Internal Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectalgae-
Palavras-chave: dc.subjectcolitis-
Palavras-chave: dc.subjectcytb-
Palavras-chave: dc.subjectdog-
Palavras-chave: dc.subjectPrototheca spp.-
Palavras-chave: dc.subjectsystemic infection-
Título: dc.titleGenotyping and drug susceptibility profiling of Prototheca sp. strains isolated from cases of protothecosis in dogs-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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