Influence of polymorphisms in IRS1, IRS2, MC3R, and MC4R on metabolic and inflammatory status and food intake in Brazilian adults: An exploratory pilot study

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidad de La Frontera-
Autor(es): dc.contributorBoston Children's Hospital-
Autor(es): dc.contributorInstitute of Cardiology Dante Pazzanese-
Autor(es): dc.contributorHospital Beneficiencia Portuguesa de Sao Paulo-
Autor(es): dc.contributorMethodist University of Piracicaba-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorFajardo, Cristina Moreno-
Autor(es): dc.creatorCerda, Alvaro-
Autor(es): dc.creatorBortolin, Raul Hernandes-
Autor(es): dc.creatorde Oliveira, Raquel-
Autor(es): dc.creatorStefani, Tamires Invencioni Moraes-
Autor(es): dc.creatordos Santos, Marina Aparecida-
Autor(es): dc.creatorBraga, Aécio Assunção-
Autor(es): dc.creatorDorea, Egídio Lima-
Autor(es): dc.creatorBernik, Márcia Martins Silveira-
Autor(es): dc.creatorBastos, Gisele Medeiros-
Autor(es): dc.creatorSampaio, Marcelo Ferraz-
Autor(es): dc.creatorDamasceno, Nágila Raquel Teixeira-
Autor(es): dc.creatorVerlengia, Rozangela-
Autor(es): dc.creatorde Oliveira, Maria Rita Marques-
Autor(es): dc.creatorHirata, Mario Hiroyuki-
Autor(es): dc.creatorHirata, Rosario Dominguez Crespo-
Data de aceite: dc.date.accessioned2025-08-21T19:02:25Z-
Data de disponibilização: dc.date.available2025-08-21T19:02:25Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.nutres.2023.08.008-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308683-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308683-
Descrição: dc.descriptionPolymorphisms in genes of leptin-melanocortin and insulin pathways have been associated with obesity and type 2 diabetes. We hypothesized that polymorphisms in IRS1, IRS2, MC3R, and MC4R influence metabolic and inflammatory markers and food intake composition in Brazilian subjects. This exploratory pilot study included 358 adult subjects. Clinical, anthropometric, and laboratory data were obtained through interview and access to medical records. The variants IRS1 rs2943634 A˃C, IRS2 rs1865434 C>T, MC3R rs3746619 C>A, and MC4R rs17782313 T>C were analyzed by real-time polymerase chain reaction. Food intake composition was assessed in a group of subjects with obesity (n = 84) before and after a short-term nutritional counseling program (9 weeks). MC4R rs17782313 was associated with increased risk of obesity (P = .034). Multivariate linear regression analysis adjusted by covariates indicated associations of IRS2 rs1865434 with reduced low-density lipoprotein cholesterol and resistin, MC3R rs3746619 with high glycated hemoglobin, and IRS1 rs2943634 and MC4R rs17782313 with increased high-sensitivity C-reactive protein (P < .05). Energy intake and carbohydrate and total fat intakes were reduced after the diet-oriented program (P < .05). Multivariate linear regression analysis showed associations of IRS2 rs1865434 with high basal fiber intake, IRS1 rs2943634 with low postprogram carbohydrate intake, and MC4R rs17782313 with low postprogram total fat and saturated fatty acid intakes (P < .05). Although significant associations did not survive correction for multiple comparisons using the Benjamini-Hochberg method in this exploratory study, polymorphisms in IRS1, IRS2, MC3R, and MC4R influence metabolic and inflammatory status in Brazilian adults. IRS1 and MC4R variants may influence carbohydrate, total fat, and saturated fatty acid intakes in response to a diet-oriented program in subjects with obesity.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Clinical and Toxicological Analyses School of Pharmaceutical Sciences University of Sao Paulo-
Descrição: dc.descriptionDepartment of Basic Sciences Center of Excellence in Translational Medicine CEMT-BIOREN Universidad de La Frontera-
Descrição: dc.descriptionDepartment of Cardiology Boston Children's Hospital-
Descrição: dc.descriptionMedical Clinic Division University Hospital University of Sao Paulo-
Descrição: dc.descriptionLaboratory of Molecular Research in Cardiology Institute of Cardiology Dante Pazzanese-
Descrição: dc.descriptionHospital Beneficiencia Portuguesa de Sao Paulo-
Descrição: dc.descriptionMedical Clinic Division Institute of Cardiology Dante Pazzanese-
Descrição: dc.descriptionDepartment of Nutrition School of Public Health University of Sao Paulo-
Descrição: dc.descriptionResearch Laboratory in Human Performance Methodist University of Piracicaba-
Descrição: dc.descriptionDepartment of Education Institute of Biosciences Sao Paulo State University-
Descrição: dc.descriptionDepartment of Education Institute of Biosciences Sao Paulo State University-
Descrição: dc.descriptionCNPq: 457334/2013-4-
Descrição: dc.descriptionCNPq: 462778/2014-2-
Formato: dc.format21-32-
Idioma: dc.languageen-
Relação: dc.relationNutrition Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCardiometabolic risk-
Palavras-chave: dc.subjectGenetic polymorphism-
Palavras-chave: dc.subjectInsulin receptor substrate-
Palavras-chave: dc.subjectMelanocortin receptor-
Palavras-chave: dc.subjectNutrigenetics-
Palavras-chave: dc.subjectObesity-
Título: dc.titleInfluence of polymorphisms in IRS1, IRS2, MC3R, and MC4R on metabolic and inflammatory status and food intake in Brazilian adults: An exploratory pilot study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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