Safety and efficacy indicators of guarana and Brazil nut extract carried in nanoparticles of coenzyme Q10: Evidence from human blood cells and red earthworm experimental model

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Autor(es): dc.contributorGraduate Program in Biotechnology - Federal University of Amazonas-
Autor(es): dc.contributorOpen University for the Third Age Foundation-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBiogenomics Laboratory - Federal University of Santa Maria-
Autor(es): dc.contributorFederal University of Santa Maria-
Autor(es): dc.creatorAzzolin, Vitória Farina-
Autor(es): dc.creatorAzzolin, Verônica Farina-
Autor(es): dc.creatorda Silva Maia, Railla-
Autor(es): dc.creatorMastella, Moises Henrique-
Autor(es): dc.creatorSasso, Juliane Santiago-
Autor(es): dc.creatorBarbisan, Fernanda-
Autor(es): dc.creatorBitencourt, Gustavo Rossato-
Autor(es): dc.creatorde Azevedo Mello, Paola-
Autor(es): dc.creatorRibeiro, Ednea Maia Aguiar-
Autor(es): dc.creatorRibeiro, Euler Esteves-
Autor(es): dc.creatorNunomura, Rita de Cassia Saraiva-
Autor(es): dc.creatorManica da Cruz, Ivana Beatrice-
Data de aceite: dc.date.accessioned2025-08-21T18:35:27Z-
Data de disponibilização: dc.date.available2025-08-21T18:35:27Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.fct.2024.114828-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308674-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308674-
Descrição: dc.descriptionThis study characterized a nanosupplement based on coenzyme Q10 containing guarana (Paullinia cupana) and Brazil nuts oil (Bertholetia excelsa) (G-Nut). Determined cytotoxic and oxi-immunomodulatory effects on human peripheral blood mononuclear cells (PBMCs) and its effect on mortality of red Californian earthworms (Eisenia fetida) and on the immune efficiency of its coelomocytes immune by in vitro exposure to yeast dead microorganism. The cytotoxic and immunomodulatory effects of G-Nut and the GN-Free extract (0.25–3 mg/mL) were determined in PBMC cultures. Apoptotic, oxidative, and inflammatory markers were determined using biochemical, immunological, and molecular protocols. The effects of G-Nut and GN-Free extracts on mortality and immune efficiency were investigated in earthworms. G-Nut and GN-Free did not induce cytotoxic events in PBMCs, triggering the decrease in apoptotic (caspases 3 and 8) gene expression, lipid and protein oxidation levels, or pro-inflammatory cytokine levels. G-Nut and GN-Free did not trigger earthworm mortality and improved coelomocyte immune efficiency by increasing Eisenia neutrophil extracellular DNA traps and brown body formation when exposed to dead yeasts. The G-Nut nanoformulation is safe and can be used as a new form of food supplement by oral or transdermal delivery.-
Descrição: dc.descriptionGraduate Program in Biotechnology - Federal University of Amazonas, AM-
Descrição: dc.descriptionOpen University for the Third Age Foundation, AM-
Descrição: dc.descriptionSão Paulo State University, SP-
Descrição: dc.descriptionBiogenomics Laboratory - Federal University of Santa Maria, RS-
Descrição: dc.descriptionGraduate Program in Chemistry Federal University of Santa Maria, RS-
Descrição: dc.descriptionSão Paulo State University, SP-
Idioma: dc.languageen-
Relação: dc.relationFood and Chemical Toxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBertholletia excelsa-
Palavras-chave: dc.subjectCoenzyme Q10-
Palavras-chave: dc.subjectNanoparticle-
Palavras-chave: dc.subjectOxy-inflammatory-
Palavras-chave: dc.subjectPaullinia cupana-
Título: dc.titleSafety and efficacy indicators of guarana and Brazil nut extract carried in nanoparticles of coenzyme Q10: Evidence from human blood cells and red earthworm experimental model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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