The Impact of miR-155-5p on Myotube Differentiation: Elucidating Molecular Targets in Skeletal Muscle Disorders

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversal Scientific Education and Research Network (USERN)-
Autor(es): dc.contributorUdeA-
Autor(es): dc.contributorUniversity of South Florida-
Autor(es): dc.creatorLopes, Letícia Oliveira-
Autor(es): dc.creatorCury, Sarah Santiloni-
Autor(es): dc.creatorde Moraes, Diogo-
Autor(es): dc.creatorOliveira, Jakeline Santos-
Autor(es): dc.creatorde Oliveira, Grasieli-
Autor(es): dc.creatorCabral-Marques, Otavio-
Autor(es): dc.creatorFernandez, Geysson Javier-
Autor(es): dc.creatorHirata, Mario Hiroyuki-
Autor(es): dc.creatorWang, Da-Zhi-
Autor(es): dc.creatorDal-Pai-Silva, Maeli-
Autor(es): dc.creatorCarvalho, Robson Francisco-
Autor(es): dc.creatorFreire, Paula Paccielli-
Data de aceite: dc.date.accessioned2025-08-21T21:12:52Z-
Data de disponibilização: dc.date.available2025-08-21T21:12:52Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms25031777-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308637-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308637-
Descrição: dc.descriptionMicroRNAs are small regulatory molecules that control gene expression. An emerging property of muscle miRNAs is the cooperative regulation of transcriptional and epitranscriptional events controlling muscle phenotype. miR-155 has been related to muscular dystrophy and muscle cell atrophy. However, the function of miR-155 and its molecular targets in muscular dystrophies remain poorly understood. Through in silico and in vitro approaches, we identify distinct transcriptional profiles induced by miR-155-5p in muscle cells. The treated myotubes changed the expression of 359 genes (166 upregulated and 193 downregulated). We reanalyzed muscle transcriptomic data from dystrophin-deficient patients and detected overlap with gene expression patterns in miR-155-treated myotubes. Our analysis indicated that miR-155 regulates a set of transcripts, including Aldh1l, Nek2, Bub1b, Ramp3, Slc16a4, Plce1, Dync1i1, and Nr1h3. Enrichment analysis demonstrates 20 targets involved in metabolism, cell cycle regulation, muscle cell maintenance, and the immune system. Moreover, digital cytometry confirmed a significant increase in M2 macrophages, indicating miR-155’s effects on immune response in dystrophic muscles. We highlight a critical miR-155 associated with disease-related pathways in skeletal muscle disorders.-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Clinical and Toxicological Analyses School of Pharmaceutical Sciences University of São Paulo-
Descrição: dc.descriptionDepartment of Immunology Institute of Biomedical Sciences University of São Paulo-
Descrição: dc.descriptionNetwork of Immunity in Infection Malignancy and Autoimmunity (NIIMA) Universal Scientific Education and Research Network (USERN)-
Descrição: dc.descriptionDepartment of Medicine Division of Molecular Medicine University of São Paulo School of Medicine-
Descrição: dc.descriptionLaboratory of Medical Investigation 29 University of São Paulo School of Medicine-
Descrição: dc.descriptionInterunit Postgraduate Program on Bioinformatics Institute of Mathematics and Statistics (IME) University of São Paulo-
Descrição: dc.descriptionCollege of Medicine University of Antioquia UdeA-
Descrição: dc.descriptionHealth Heart Institute Center for Regenerative Medicine University of South Florida-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDMD-
Palavras-chave: dc.subjectmicroRNA-
Palavras-chave: dc.subjectmiR-155-
Palavras-chave: dc.subjectmuscular dystrophies-
Palavras-chave: dc.subjectnon-coding RNAs-
Palavras-chave: dc.subjectRNA sequencing-
Título: dc.titleThe Impact of miR-155-5p on Myotube Differentiation: Elucidating Molecular Targets in Skeletal Muscle Disorders-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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