Microbiota, mitochondria, and epigenetics in health and disease: converging pathways to solve the puzzle

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidad de Buenos Aires-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorInstituto de Medicina y Biología Experimental de Cuyo (IMBECU) CONICET-Universidad Nacional de Cuyo-
Autor(es): dc.contributorUniversidad Nacional de Cuyo-
Autor(es): dc.creatorRukavina Mikusic, Natalia Lucia-
Autor(es): dc.creatorPrince, Paula Denise-
Autor(es): dc.creatorChoi, Marcelo Roberto-
Autor(es): dc.creatorChuffa, Luiz Gustavo A.-
Autor(es): dc.creatorSimão, Vinícius Augusto-
Autor(es): dc.creatorCastro, Claudia-
Autor(es): dc.creatorManucha, Walter-
Autor(es): dc.creatorQuesada, Isabel-
Data de aceite: dc.date.accessioned2025-08-21T19:02:30Z-
Data de disponibilização: dc.date.available2025-08-21T19:02:30Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00424-025-03072-w-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308540-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308540-
Descrição: dc.descriptionDysbiosis, which refers to an imbalance in the composition of the gut microbiome, has been associated with a range of metabolic disorders, including type 2 diabetes, obesity, and metabolic syndrome. Although the exact mechanisms connecting gut dysbiosis to these conditions are not fully understood, various lines of evidence strongly suggest a substantial role for the interaction between the gut microbiome, mitochondria, and epigenetics. Current studies suggest that the gut microbiome has the potential to affect mitochondrial function and biogenesis through the production of metabolites. A well-balanced microbiota plays a pivotal role in supporting normal mitochondrial and cellular functions by providing metabolites that are essential for mitochondrial bioenergetics and signaling pathways. Conversely, in the context of illnesses, an unbalanced microbiota can impact mitochondrial function, leading to increased aerobic glycolysis, reduced oxidative phosphorylation and fatty acid oxidation, alterations in mitochondrial membrane permeability, and heightened resistance to cellular apoptosis. Mitochondrial activity can also influence the composition and function of the gut microbiota. Because of the intricate interplay between nuclear and mitochondrial communication, the nuclear epigenome can regulate mitochondrial function, and conversely, mitochondria can produce metabolic signals that initiate epigenetic changes within the nucleus. Given the epigenetic modifications triggered by metabolic signals from mitochondria in response to stress or damage, targeting an imbalanced microbiota through interventions could offer a promising strategy to alleviate the epigenetic alterations arising from disrupted mitochondrial signaling.-
Descrição: dc.descriptionInstituto Alberto C. Taquini de Investigaciones en Medicina Traslacional (IATIMET) CONICET Universidad de Buenos Aires-
Descrição: dc.descriptionDepartamento de Ciencias Biológicas Cátedra de Anatomía E Histología Facultad de Farmacia y Bioquímica Universidad de Buenos Aires-
Descrição: dc.descriptionDepartamento de Ciencias Químicas Cátedra de Fisicoquímica Facultad de Farmacia y Bioquímica Universidad de Buenos Aires-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences UNESP - São Paulo State University, P.O. Box 18618-689, São Paulo-
Descrição: dc.descriptionInstituto de Medicina y Biología Experimental de Cuyo (IMBECU) CONICET-Universidad Nacional de Cuyo-
Descrição: dc.descriptionLaboratorio de Farmacología Básica y Traslacional Área de Farmacología Departamento de Patología Facultad de Ciencias Médicas Universidad Nacional de Cuyo-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences UNESP - São Paulo State University, P.O. Box 18618-689, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationPflugers Archiv European Journal of Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEpigenetics-
Palavras-chave: dc.subjectMetabolic syndrome-
Palavras-chave: dc.subjectMicrobiota-
Palavras-chave: dc.subjectMitochondria-
Título: dc.titleMicrobiota, mitochondria, and epigenetics in health and disease: converging pathways to solve the puzzle-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.