In vitro effects of selective serotonin reuptake inhibitors on Cryptococcus gattii capsule and biofilm

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de Guarulhos-
Autor(es): dc.creatorViveiro, Letícia Rampazzo Da Gama-
Autor(es): dc.creatorRehem, Amanda Rodrigues-
Autor(es): dc.creatorSantos, Evelyn Luzia De Souza-
Autor(es): dc.creatorCarmo, Paulo Henrique Fonseca Do-
Autor(es): dc.creatorJunqueira, Juliana Campos-
Autor(es): dc.creatorScorzoni, Liliana-
Data de aceite: dc.date.accessioned2025-08-21T17:51:56Z-
Data de disponibilização: dc.date.available2025-08-21T17:51:56Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/femspd/ftae001-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308535-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308535-
Descrição: dc.descriptionInfections caused by Cryptococcus gattii mainly affect immunocompetent individuals and the treatment presents important limitations. This study aimed to validate the efficacy of selective serotonin reuptake inhibitors (SSRI), fluoxetine hydrochloride (FLH), and paroxetine hydrochloride (PAH) in vitro against C. gattii. The antifungal activity of SSRI using the microdilution method revealed a minimal inhibitory concentration (MIC) of 31.25 μg/ml. The combination of FLH or PAH with amphotericin B (AmB) was analyzed using the checkerboard assay and the synergistic effect of SSRI in combination with AmB was able to reduce the SSRI or AmB MIC values 4-8-fold. When examining the effect of SSRI on the induced capsules, we observed that FLH and PAH significantly decreased the size of C. gattii capsules. In addition, the effects of FLH and PAH were evaluated in biofilm biomass and viability. The SSRI were able to reduce biofilm biomass and biofilm viability. In conclusion, our results indicate the use of FLH and PAH exhibited in vitro anticryptococcal activity, representing a possible future alternative for the cryptococcosis treatment.-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP)-
Descrição: dc.descriptionPrograma de Pós-Graduação em Enfermagem Universidade de Guarulhos, Guarulhos-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationPathogens and Disease-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntifungal-
Palavras-chave: dc.subjectBiofilm-
Palavras-chave: dc.subjectCryptococcus gattii-
Palavras-chave: dc.subjectSerotonin reuptake inhibitors-
Título: dc.titleIn vitro effects of selective serotonin reuptake inhibitors on Cryptococcus gattii capsule and biofilm-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.