Potential Biomarkers Indicating Resistance or Resilience in Experimental Peri-Implant Mucositis: A Systematic Review and Meta-Analysis

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorHuamán-Mendoza, Aldrin André-
Autor(es): dc.creatordo Amaral, Guilherme Castro Lima Silva-
Autor(es): dc.creatorVilela, Nathalia-
Autor(es): dc.creatorChuquimez-Ventura, Casimira Valeria-
Autor(es): dc.creatorRovai, Emanuel Silva-
Autor(es): dc.creatorRomito, Giuseppe Alexandre-
Autor(es): dc.creatorPannuti, Claudio Mendes-
Autor(es): dc.creatorVillar, Cristina Cunha-
Autor(es): dc.creatorHolzhausen, Marinella-
Data de aceite: dc.date.accessioned2025-08-21T21:45:04Z-
Data de disponibilização: dc.date.available2025-08-21T21:45:04Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/clr.14427-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308422-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308422-
Descrição: dc.descriptionObjectives: To identify changes in immunological, microbiological, and histological biomarkers that may indicate resistance during the induction phase and resilience during the resolution phase of experimental peri-implant mucositis (PiM). Materials and Methods: The search was performed in MEDLINE, EMBASE, Web of Science, SCOPUS, Cochrane Library, and LILACS databases. Prospective interventional studies assessing biomarkers during experimental PiM were included. The risk of bias was assessed using the Risk Of Bias In Non-Randomized Studies of Interventions (ROBINS-I) tool. Meta-analyses were conducted using random-effects models. The GRADE approach was used to determine the certainty of evidence. Results: Eleven out of 6008 studies were included. Clinical parameters (mPI and mGI) effectively characterized the experimental PiM model. Due to methodological variability and conflicting results, a definitive interpretation of microbiological and histological biomarkers was not possible. The meta-analysis revealed that IL-1β and the volume of peri-implant crevicular fluid (PICF) indicated non-resistance during the induction phase. In contrast, TNF-α, IL-6, IL-8, IL-17, MMP-8, and IFN-γ remained stable. Regarding the resolution phase, IL-1β returned to baseline levels (SMD: 1.13; 95% CI: −0.81, 3.06), and the volume of PICF (MD: 0.08; 95% CI: 0.03, 0.13) remained significantly elevated compared to day 0. However, TNF-α, IL-6, IL-8, IL-17, MMP-8, and IFN-γ did not significantly differ from baseline levels. Conclusions: Moderate to very low evidence suggested that the biomarkers IL-1β and the volume of PICF indicated a lack of resistance while suggesting resilience and non-resilience, respectively. The biomarkers TNF-α, IL-6, IL-8, IL-17, MMP-8, and IFN-γ demonstrated resistance and resilience.-
Descrição: dc.descriptionDivision of Periodontics Department of Stomatology School of Dentistry University of São Paulo (USP), São Paulo-
Descrição: dc.descriptionDivision of Periodontics Institute of Science and Technology São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDivision of Periodontics Institute of Science and Technology São Paulo State University (UNESP), São Paulo-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Implants Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiomarkers-
Palavras-chave: dc.subjectdental implants-
Palavras-chave: dc.subjectevidence-based dentistry-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectmeta-analysis-
Palavras-chave: dc.subjectsystematic review-
Título: dc.titlePotential Biomarkers Indicating Resistance or Resilience in Experimental Peri-Implant Mucositis: A Systematic Review and Meta-Analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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