Integrative dereplication and molecular networking reveal potential antimicrobial agents in Kielmeyera coriacea Mart.

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Autor(es): dc.contributorUniversidade Tecnológica Federal do Paraná (UTFPR)-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.creatorCoqueiro, Aline-
Autor(es): dc.creatorWakui, Vinicius Galvão-
Autor(es): dc.creatorPilon, Alan C.-
Autor(es): dc.creatorCastilho, Nathália S.-
Autor(es): dc.creatorCosta, Eliângela C. C.-
Autor(es): dc.creatorMonteiro, Afif F.-
Autor(es): dc.creatorAnjos, Charlene S. dos-
Autor(es): dc.creatorLeandro, Luis Fernando-
Autor(es): dc.creatorMartins, Carlos Henrique Gomes-
Autor(es): dc.creatorPasqualotto Severino, Vanessa G.-
Data de aceite: dc.date.accessioned2025-08-21T22:16:35Z-
Data de disponibilização: dc.date.available2025-08-21T22:16:35Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/14786419.2025.2465605-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308418-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308418-
Descrição: dc.descriptionKielmeyera coriacea Mart., native to Brazilian Cerrado, is traditionally used in folk medicine. The MIC against bacteria and yeasts was determined for the ethanolic extracts of roots, outer bark, leaves, and fruits. A dereplication strategy via HPLC-ESI-HRMS/MS and GNPS was used to identify known compounds and highlight potential compounds responsible for the activities. The root extract exhibited the most promising activity against a range of bacteria and fungi. This extract was selected for further fractionation, yielding n-hexane, ethyl acetate, and hydroalcoholic fractions. These were evaluated against the same microbial strains. Subsequent chromatographic analysis and bioactivity tests identified two highly active subfractions from the n-hexane and hydroalcoholic fractions. Detailed analysis using standards and databases (GNPS and Scifinder) led to the annotation of three xanthones (kielcorin, and its hydroxy- and methoxy- derivatives), three glycosylated flavonoids, and two acylphoroglucinol derivatives (garcinielliptone D e A).-
Descrição: dc.descriptionChemistry Department Universidade Tecnológica Federal do Paraná (UTFPR), PR-
Descrição: dc.descriptionChemistry Institute Universidade Federal de Goiás, GO-
Descrição: dc.descriptionChemistry Department Universidade Estadual Paulista, SP-
Descrição: dc.descriptionInstitute of Chemistry Universidade Estadual de Campinas, SP-
Descrição: dc.descriptionInstitute of Biomedical Sciences Universidade Federal de Uberlândia-
Descrição: dc.descriptionChemistry Department Universidade Estadual Paulista, SP-
Idioma: dc.languageen-
Relação: dc.relationNatural Product Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectacylphoroglucinol-
Palavras-chave: dc.subjectantibacterial-
Palavras-chave: dc.subjectantifungal-
Palavras-chave: dc.subjectdereplication-
Palavras-chave: dc.subjectKielmeyera coriacea-
Título: dc.titleIntegrative dereplication and molecular networking reveal potential antimicrobial agents in Kielmeyera coriacea Mart.-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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