Combination of a Synthetic Bioceramic Associated with a Polydioxanone-Based Membrane as an Alternative to Autogenous Bone Grafting

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorTufts University School of Dental Medicine-
Autor(es): dc.contributorGuarulhos University-
Autor(es): dc.creatorFrigério, Paula Buzo-
Autor(es): dc.creatorde Moura, Juliana-
Autor(es): dc.creatorPitol-Palin, Letícia-
Autor(es): dc.creatorMonteiro, Naara Gabriela-
Autor(es): dc.creatorMourão, Carlos Fernando-
Autor(es): dc.creatorShibli, Jamil Awad-
Autor(es): dc.creatorOkamoto, Roberta-
Data de aceite: dc.date.accessioned2025-08-21T21:23:56Z-
Data de disponibilização: dc.date.available2025-08-21T21:23:56Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/biomimetics9050284-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308394-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308394-
Descrição: dc.descriptionThe purpose of this study was to evaluate the repair process in rat calvaria filled with synthetic biphasic bioceramics (Plenum® Osshp-70:30, HA:βTCP) or autogenous bone, covered with a polydioxanone membrane (PDO). A total of 48 rats were divided into two groups (n = 24): particulate autogenous bone + Plenum® Guide (AUTOPT+PG) or Plenum® Osshp + Plenum® Guide (PO+PG). A defect was created in the calvaria, filled with the grafts, and covered with a PDO membrane, and euthanasia took place at 7, 30, and 60 days. Micro-CT showed no statistical difference between the groups, but there was an increase in bone volume (56.26%), the number of trabeculae (2.76 mm), and intersection surface (26.76 mm2) and a decrease in total porosity (43.79%) in the PO+PG group, as well as higher values for the daily mineral apposition rate (7.16 µm/day). Histometric analysis presented material replacement and increased bone formation at 30 days compared to 7 days in both groups. Immunostaining showed a similar pattern between the groups, with an increase in proteins related to bone remodeling and formation. In conclusion, Plenum® Osshp + Plenum® Guide showed similar and sometimes superior results when compared to autogenous bone, making it a competent option as a bone substitute.-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionDepartment of Periodontology Tufts University School of Dental Medicine-
Descrição: dc.descriptionDepartment of Periodontology Dental Research Division Guarulhos University-
Descrição: dc.descriptionDepartment of Basic Sciences São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionDepartment of Basic Sciences São Paulo State University (UNESP) School of Dentistry-
Idioma: dc.languageen-
Relação: dc.relationBiomimetics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbioceramics-
Palavras-chave: dc.subjectbone grafting-
Palavras-chave: dc.subjectbone substitutes-
Palavras-chave: dc.subjectguided bone regeneration-
Palavras-chave: dc.subjectguided tissue regeneration-
Palavras-chave: dc.subjectsynthetic polymer-
Título: dc.titleCombination of a Synthetic Bioceramic Associated with a Polydioxanone-Based Membrane as an Alternative to Autogenous Bone Grafting-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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