In vitro antimicrobial activity of non-traditional therapies for infectious endometritis in mares

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Illinois Urbana—Champaign-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Caxias do Sul (UCS)-
Autor(es): dc.contributorRoss University School of Veterinary Medicine-
Autor(es): dc.creatorMazzuchini, Mariana P.-
Autor(es): dc.creatorLisboa, Fernando Paixão-
Autor(es): dc.creatorde Castro, Jessica I.-
Autor(es): dc.creatorAlvarenga, Marco A.-
Autor(es): dc.creatorSegabinazzi, Lorenzo G. T. M.-
Autor(es): dc.creatorCanisso, Igor F.-
Data de aceite: dc.date.accessioned2025-08-21T19:24:04Z-
Data de disponibilização: dc.date.available2025-08-21T19:24:04Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/evj.14423-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308339-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308339-
Descrição: dc.descriptionBackground: Endometritis is the leading cause of subfertility in horses, and it is a clinical problem where historically antibiotics have not always been used with prudent justification. Because of this, alternative therapies to treat endometritis are necessary for the rational use of antibiotics. Objectives: To assess the in vitro antimicrobial activity of non-traditional therapies commonly used in clinical practice against microorganisms causing infectious endometritis in mares. Study design: In vitro experiments. Methods: A microdilution technique was performed to determine the minimum inhibitory concentrations (MIC) of 50%, 90% and 100% of microorganisms and the percentage of inhibition (PI) of each therapy against each microorganism (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus and Candida sp.). The MIC 50% and 90% were determined using non-linear regression, while MIC 100% was assessed using the resazurin dye technique. The serial PI was evaluated for each therapy using a spectrophotometer. Results: All the therapies demonstrated a PI higher than positive controls for all microorganisms (p < 0.05); however, the only therapies that presented MIC 100 values were hydrogen peroxide and platelet-rich and -poor plasma. Main limitations: In vivo, safety and treatment efficacy were not tested. Conclusion: Hydrogen peroxide and platelet-rich and -poor plasma might be alternatives to traditional therapies for endometritis to support a reduction in antibiotic use.-
Descrição: dc.descriptionDepartment of Veterinary Clinical Medicine College of Veterinary Medicine University of Illinois Urbana—Champaign-
Descrição: dc.descriptionDepartment of Animal Reproduction and Veterinary Radiology São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionInstitute of Biotechnology University of Caxias do Sul (UCS), Rio Grande do Sul-
Descrição: dc.descriptionRoss University School of Veterinary Medicine, West Indies, St. Kitts-
Descrição: dc.descriptionDepartment of Animal Reproduction and Veterinary Radiology São Paulo State University (UNESP), São Paulo-
Idioma: dc.languageen-
Relação: dc.relationEquine Veterinary Journal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantibiotics-
Palavras-chave: dc.subjectbacteria-
Palavras-chave: dc.subjectfungus-
Palavras-chave: dc.subjecthorse-
Palavras-chave: dc.subjectinfection-
Palavras-chave: dc.subjectsubfertility-
Título: dc.titleIn vitro antimicrobial activity of non-traditional therapies for infectious endometritis in mares-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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