Increase Toll-like receptors 2 and 4 in apical periodontitis of rats with chronic liver disease

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorDental School of Amazonas State University-
Autor(es): dc.contributorUniversity of Sevilla-
Autor(es): dc.creatorCantiga-Silva, Cristiane-
Autor(es): dc.creatorde Oliveira, Pedro Henrique Chaves-
Autor(es): dc.creatorFaria, Flávio Duarte-
Autor(es): dc.creatorJusto, Mariana Pagliusi-
Autor(es): dc.creatorSivieri-Araújo, Gustavo-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorPinheiro, Tiago Novaes-
Autor(es): dc.creatorSegura-Egea, Juan José-
Autor(es): dc.creatorCintra, Luciano Tavares Angelo-
Data de aceite: dc.date.accessioned2025-08-21T20:24:13Z-
Data de disponibilização: dc.date.available2025-08-21T20:24:13Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10266-024-00974-6-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308289-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308289-
Descrição: dc.descriptionThe aim of this study was to evaluate the influence of liver fibrosis (LF) on the expression of Toll-like receptors (TLR) 2 and 4 in apical periodontitis (AP) in Wistar rats. Forty Wistar rats were allocated in the following groups (n = 10): C—control; AP—apical periodontitis; LF—liver fibrosis; AP + LF—rats with AP and LF. LF and AP were induced by established methodologies. Histological, bacteriological, and immunohistochemical analyses were performed according to pre-established scores. For comparisons between AP and AP + LF groups, the Mann–Whitney test was used (P <.05). The livers of the LF and AP + LF groups showed generalized portal inflammatory infiltrate and collagen fibers confirming the presence of LF. Histopathological analysis in the maxilla of the AP + LF group showed areas of necrosis comprising the entire dental pulp and periapical tissue surrounded by a more intense inflammatory infiltrate than observed in the AP group (P = 0.032). A significant number of specimens in the AP + LF group showed microorganisms beyond the apical foramen adhered to the extraradicular biofilm, demonstrating greater invasion compared to the AP group (P =.008). Immunohistochemical analysis showed a large number of cells immunoreactive for TLR2 and TLR4 in the AP + LF group, compared to the AP group (P < 0.05). Liver fibrosis favors the inflammation and contamination of microorganisms in apical periodontitis and triggers the expression of TLR2 and TLR4, modulating innate immunity response in periapical lesions.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado do Amazonas-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionEndodontic Section Department of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Basic Science School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Oral Pathology and Oral Medicine Dental School of Amazonas State University, AM-
Descrição: dc.descriptionEndodontic Section Department of Stomatology School of Dentistry University of Sevilla-
Descrição: dc.descriptionEndodontic Section Department of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Basic Science School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado do Amazonas: 01.01.016301.000658.2018-
Descrição: dc.descriptionFAPESP: 2020/09695-5-
Formato: dc.format296-304-
Idioma: dc.languageen-
Relação: dc.relationOdontology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectApical periodontitis-
Palavras-chave: dc.subjectLiver disease-
Palavras-chave: dc.subjectLiver fibrosis-
Palavras-chave: dc.subjectToll-like receptors-
Título: dc.titleIncrease Toll-like receptors 2 and 4 in apical periodontitis of rats with chronic liver disease-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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