Brown spider venom phospholipases D: From molecular biology and structural analyses to potential vaccine and serum therapy applications

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal do Paraná (UFPR)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPolli, Nayanne Louise Costacurta-
Autor(es): dc.creatorBaldissera, Antonielle-
Autor(es): dc.creatorde Oliveira Leite, Isabel-
Autor(es): dc.creatorGonzalez, Jorge Enrique Hernandez-
Autor(es): dc.creatorGismene, Carolina-
Autor(es): dc.creatorMariutti, Ricardo Barros-
Autor(es): dc.creatorMatsubara, Fernando Hitomi-
Autor(es): dc.creatorSenff-Ribeiro, Andrea-
Autor(es): dc.creatorArni, Raghuvir Krishnaswamy-
Autor(es): dc.creatorVeiga, Silvio Sanches-
Autor(es): dc.creatorGremski, Luiza Helena-
Data de aceite: dc.date.accessioned2025-08-21T18:18:42Z-
Data de disponibilização: dc.date.available2025-08-21T18:18:42Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/B978-0-443-15313-6.00004-1-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308276-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308276-
Descrição: dc.descriptionIn this chapter, we initially elaborate on the identification and characterization of brown spider venom phospholipases D (BSVPLDs) based on “omics” approaches, with an emphasis on transcriptomic and proteomic analyses. Subsequently, we describe the production of recombinant BSVPLDs and the main challenges associated with the purification of these proteins directly from crude venoms. After that, the biophysical and structural aspects are described. We conclude by describing how recombinant BSVPLDs have been engineered to be used in therapeutic applications, such as in vaccine development, as a new generation serum, and as a putative model for the development of drugs.-
Descrição: dc.descriptionDepartment of Cell Biology Federal University of Paraná (UFPR), Paraná-
Descrição: dc.descriptionMultiuser Center for Biomolecular Innovation Department of Physics Universidade Estadual Paulista (UNESP), São Paulo-
Descrição: dc.descriptionMultiuser Center for Biomolecular Innovation Department of Physics Universidade Estadual Paulista (UNESP), São Paulo-
Formato: dc.formatV1-263-V1-286-
Idioma: dc.languageen-
Relação: dc.relationPhospholipases in Physiology and Pathology: Volumes 1-7-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntivenom-
Palavras-chave: dc.subjectLoxosceles-
Palavras-chave: dc.subjectLoxoscelism-
Palavras-chave: dc.subjectPhospholipid-
Palavras-chave: dc.subjectSphingomyelinases-
Palavras-chave: dc.subjectToxin-
Título: dc.titleBrown spider venom phospholipases D: From molecular biology and structural analyses to potential vaccine and serum therapy applications-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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