The incidence of osteoradionecrosis of the jaws in oral cavity cancer patients treated with intensity-modulated radiotherapy: a systematic review and meta-analysis

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorde Almeida-Silva, Luis Augusto-
Autor(es): dc.creatorLupp, Juliana dos Santos-
Autor(es): dc.creatorSobral-Silva, Leonardo Alvares-
Autor(es): dc.creatordos Santos, Luiz Augusto Rodrigues-
Autor(es): dc.creatorMarques, Thays Oliveira-
Autor(es): dc.creatorda Silva, Danillo Babinskas Ribeiro-
Autor(es): dc.creatorCaneppele, Taciana Marco Ferraz-
Autor(es): dc.creatorBianchi-de-Moraes, Michelle-
Data de aceite: dc.date.accessioned2025-08-21T16:41:48Z-
Data de disponibilização: dc.date.available2025-08-21T16:41:48Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.oooo.2024.04.008-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308255-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308255-
Descrição: dc.descriptionObjective: A systematic review with meta-analysis was conducted to define the incidence of osteoradionecrosis (ORN) in patients with oral cavity cancer (OCC) treated with intensity-modulated radiotherapy (IMRT), and to identify the risk factors influencing its development. Study Design: Six databases were searched systematically. A meta-analysis was performed to determine overall, spontaneous, and dental extraction-attributed incidences of ORN. The Grading of Recommendations Assessment, Development, and Evaluation tool evaluated evidence certainty. Results: Out of 11 eligible studies, 6 underwent meta-analysis for the overall aggregated ORN incidence in OCC patients receiving IMRT, resulting in an incidence rate of 8% (95% CI: 6%-11%). Regarding development reasons, 2 studies were assessed, revealing an incidence of 36% (95% CI: 1%-98%) for spontaneous ORN, and 17% (95% CI: 5%-44%) ensued from dental extraction exclusively pre-RT. All rates had very low certainty of evidence. Factors significantly correlated with ORN development included postoperative RT use (78%), employment of therapeutic doses above 50 Gy, and mandibular involvement (80.5%). Conclusion: The findings suggest that IMRT alone is not sufficient to decrease ORN rates in OCC patients, underscoring the importance of precisely identifying the involved risk factors. However, further detailed primary studies will be necessary.-
Descrição: dc.descriptionDepartment of Bioscience and Oral Diagnosis Institute of Science and Technology São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Surgery and Diagnosis Institute of Science and Technology São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Restorative Dentistry Institute of Science and Technology São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Bioscience and Oral Diagnosis Institute of Science and Technology São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Surgery and Diagnosis Institute of Science and Technology São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Restorative Dentistry Institute of Science and Technology São Paulo State University (Unesp)-
Formato: dc.format66-78-
Idioma: dc.languageen-
Relação: dc.relationOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology-
???dc.source???: dc.sourceScopus-
Título: dc.titleThe incidence of osteoradionecrosis of the jaws in oral cavity cancer patients treated with intensity-modulated radiotherapy: a systematic review and meta-analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.