In Vitro and In Vivo Evaluation of Magnetic Floating Dosage Form by Alternating Current Biosusceptometry

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPonta Grossa State University-
Autor(es): dc.creatorRodrigues, Gustavo Serafim-
Autor(es): dc.creatorBarboza, João Miguel-
Autor(es): dc.creatorBuranello, Laís Pereira-
Autor(es): dc.creatorBrandão, Vitor Melo-
Autor(es): dc.creatorFerrari, Priscileila Colerato-
Autor(es): dc.creatorSoares, Guilherme Augusto-
Autor(es): dc.creatorMiranda, José Ricardo de Arruda-
Data de aceite: dc.date.accessioned2025-08-21T16:06:10Z-
Data de disponibilização: dc.date.available2025-08-21T16:06:10Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/pharmaceutics16030351-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308176-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308176-
Descrição: dc.descriptionFloating controlled systems seek to extend the gastric retention time (GRT) of solid pharmaceutical forms by sustaining buoyancy in the stomach without affecting gastric emptying rates. This investigation aimed to evaluate a magnetic floating drug delivery system (MFDDS) under diverse physiological conditions (pressure and viscosity) using an Alternating Current Biosusceptometry (ACB) system by conducting assessments in vitro and in vivo. For in vitro experiments, MFDDSs were placed under different pressures (760, 910, and 1060 mmHg) and viscosities (1, 50, 120, and 320 mPa·s) for evaluation of floating lag time (FLT). For in vivo experiments, eight healthy volunteers participated in two phases (fasting and fed) for gastric parameters (GRT, FLT, and OCTT—orocaecal transit time) assessment, employing the ACB system. The results indicated that pressure, viscosity, and FLT were directly proportional in the in vitro assay; in addition, increases in the OCTT (fasting = 241.9 ± 18.7; fed = 300 ± 46.4), GRT (fasting = 139.4 ± 25.3; fed = 190.2 ± 47.7), and FLT (fasting = 73.1 ± 16.9; fed = 107.5 ± 29.8) were detected in vivo. Our study emphasizes that the ACB system is a valuable technique, and it is capable of tracking and imaging MFDDS in in vitro and in vivo experiments.-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences São Paulo State University—UNESP, São Paulo-
Descrição: dc.descriptionDepartment of Pharmaceutical Sciences Ponta Grossa State University, Paraná-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences São Paulo State University—UNESP, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationPharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectACB system-
Palavras-chave: dc.subjectfloating lag time (FLT)-
Palavras-chave: dc.subjectintragastric pressure-
Palavras-chave: dc.subjectmagnetic floating drug delivery systems-
Palavras-chave: dc.subjectviscosity-
Título: dc.titleIn Vitro and In Vivo Evaluation of Magnetic Floating Dosage Form by Alternating Current Biosusceptometry-
Tipo de arquivo: dc.typelivro digital-
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