Interaction of high lipogenic states with titanium on osteogenesis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorErasmus University Medical Center-
Autor(es): dc.creatorPinto, T. S.-
Autor(es): dc.creatorvan der Eerden, B. C.-
Autor(es): dc.creatorSchreuders-Koedam, M.-
Autor(es): dc.creatorvan de Peppel, J.-
Autor(es): dc.creatorAyada, I.-
Autor(es): dc.creatorPan, Q.-
Autor(es): dc.creatorVerstegen, M. M.-
Autor(es): dc.creatorvan der Laan, L. J.-
Autor(es): dc.creatorFuhler, G. M.-
Autor(es): dc.creatorZambuzzi, W. F.-
Autor(es): dc.creatorPeppelenbosch, M. P.-
Data de aceite: dc.date.accessioned2025-08-21T15:39:02Z-
Data de disponibilização: dc.date.available2025-08-21T15:39:02Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bone.2024.117242-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308152-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308152-
Descrição: dc.descriptionAs obesity rates continue to rise, the prevalence of metabolic dysfunction and alcohol-associated steatotic liver disease (MetALD), a new term for Nonalcoholic Fatty Liver Disease (NAFLD), also increases. In an aging population, it is crucial to understand the interplay between metabolic disorders, such as MetALD, and bone health. This understanding becomes particularly significant in the context of implant osseointegration. This study introduces an in vitro model simulating high lipogenesis through the use of human Mesenchymal Stroma Cells-derived adipocytes, 3D intrahepatic cholangiocyte organoids (ICO), and Huh7 hepatocytes, to evaluate the endocrine influence on osteoblasts interacting with titanium. We observed a significant increase in intracellular fat accumulation in all three cell types, along with a corresponding elevation in metabolic gene expression compared to the control groups. Notably, osteoblasts undergoing mineralization in this high-lipogenesis environment also displayed lipid vesicle accumulation. The study further revealed that titanium surfaces modulate osteogenic gene expression and impact cell cycle progression, cell survival, and extracellular matrix remodeling under lipogenic conditions. These findings provide new insights into the challenges of implant integration in patients with obesity and MetALD, offering a deeper understanding of the metabolic influences on bone regeneration and implant success.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionLab. of Bioassays and Cellular Dynamics Department of Chemical and Biological Sciences Institute of Biosciences UNESP São Paulo State University, SP-
Descrição: dc.descriptionDepartment of Internal Medicine Erasmus MC Erasmus University Medical Center-
Descrição: dc.descriptionDepartment of Gastroenterology and Hepatology Erasmus MC Erasmus University Medical Center-
Descrição: dc.descriptionDepartment of Surgery Erasmus MC Erasmus University Medical Center-
Descrição: dc.descriptionLab. of Bioassays and Cellular Dynamics Department of Chemical and Biological Sciences Institute of Biosciences UNESP São Paulo State University, SP-
Idioma: dc.languageen-
Relação: dc.relationBone-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBone regeneration-
Palavras-chave: dc.subjectLipogenic states-
Palavras-chave: dc.subjectMetabolic disorders-
Palavras-chave: dc.subjectOsteogenesis-
Palavras-chave: dc.subjectTitanium implants-
Título: dc.titleInteraction of high lipogenic states with titanium on osteogenesis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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