Plantago major leaf extract against bacteria and fungi of medical importance

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorAdolfo Lutz Institute-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorFaculdade Galileu-
Autor(es): dc.creatorde Sousa, Débora Silva Marques-
Autor(es): dc.creatorRuiz, Luciana da Silva-
Autor(es): dc.creatorPereira, Ana Flávia Marques-
Autor(es): dc.creatorSani, Alessandra Aguirra-
Autor(es): dc.creatorZapata, Tatiane Baptista-
Autor(es): dc.creatorMonari, Gabrielle Pires de Morais-
Autor(es): dc.creatorda Rosa, Cassiana Ferreira-
Autor(es): dc.creatorFernandes Junior, Ary-
Autor(es): dc.creatorRall, Vera Lucia Mores-
Autor(es): dc.creatorPrado, Diego Godina-
Autor(es): dc.creatorde Oliveira, Alberto-
Autor(es): dc.creatorBosco, Sandra de Moraes Gimenes-
Data de aceite: dc.date.accessioned2025-08-21T22:05:40Z-
Data de disponibilização: dc.date.available2025-08-21T22:05:40Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/s2175-97902025e24143-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308119-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308119-
Descrição: dc.descriptionAntimicrobial drug resistance is a challenge to public health. Various microorganisms, including methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, carbapenemase-producing Klebsiella pneumoniae, Pythium insidiosum, and Candida auris, have developed resistance to commonly used antimicrobials in infection disease treatments. Consequently, there is an urgent need to explore and develop novel therapeutic drugs. Natural products, particularly medicinal plants, have received attention in the quest for innovative treatments for various diseases. Plantago major is a plant endowed with several biological properties, such as antibacterial, antifungal, and healing actions. This study aimed to investigate the antimicrobial activities of the methanolic extract obtained from the leaves of P. major. Microdilution assays were conducted to determine the minimum inhibitory concentration and minimum bactericidal and fungicidal concentration. Additionally, synergism with antimicrobial drugs was assessed using a time-kill curve analysis. A synergistic bactericidal interaction between the extract and imipenem was observed against carbapenemase-producing K. pneumoniae. For MRSA, a bacteriostatic synergism was noted in combinations of the extract with cephalotin and oxacillin. For C. auris, a fungistatic interaction was observed between the extract and amphotericin B. These results suggest the presence of bioactive compounds within the extract with therapeutic potential for combating infections caused by these microorganisms.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionJúlio de Mesquita Filho State University of São Paulo (UNESP) Department of Chemical and Biological Sciences Microbiology and Immunology Sector, São Paulo-
Descrição: dc.descriptionAdolfo Lutz Institute-
Descrição: dc.descriptionFederal University of Uberlandia Institute of Chemistry Federal University of Uberlândia, Santa Mônica Campus, MG, Minas Gerais-
Descrição: dc.descriptionFaculdade Galileu, São Paulo-
Descrição: dc.descriptionJúlio de Mesquita Filho State University of São Paulo (UNESP) Department of Chemical and Biological Sciences Microbiology and Immunology Sector, São Paulo-
Descrição: dc.descriptionFAPESP: 2019/24850-0-
Descrição: dc.descriptionFAPESP: 2020/04211-0-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Pharmaceutical Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntimicrobial drugs-
Palavras-chave: dc.subjectExtract chemical composition-
Palavras-chave: dc.subjectMass spectrometry-
Palavras-chave: dc.subjectMulti-drug resistant microorganisms-
Palavras-chave: dc.subjectNatural products-
Palavras-chave: dc.subjectSynergistic interaction-
Título: dc.titlePlantago major leaf extract against bacteria and fungi of medical importance-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.