Bone Incorporation of a Poly (L-Lactide-Co-D, L-Lactide) Internal Fixation Device in a Rat’s Tibia: Microtomographic, Confocal LASER, and Histomorphometric Analysis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFondazione IRCCS Cà Granda Ospedale Maggiore Policlinico-
Autor(es): dc.contributorUniversity of Milan-
Autor(es): dc.contributorSão Leopoldo Mandic School of Dentistry and Research Center-
Autor(es): dc.creatorMamani-Valeriano, Harrisson Lucho-
Autor(es): dc.creatorSilva, Nelson Padilha-
Autor(es): dc.creatorNímia, Heloisa Helena-
Autor(es): dc.creatorPereira-Silva, Maísa-
Autor(es): dc.creatorOliveira, Maria Eduarda de Freitas Santana-
Autor(es): dc.creatorRodrigues, Letícia Gabriella de Souza-
Autor(es): dc.creatorTavares, Paulo Matheus Honda-
Autor(es): dc.creatorHadad, Henrique-
Autor(es): dc.creatorde Jesus, Laís Kawamata-
Autor(es): dc.creatorSantos, Ana Flávia Piquera-
Autor(es): dc.creatorBarbosa, Débora de Barros-
Autor(es): dc.creatorPoli, Pier Paolo-
Autor(es): dc.creatorMaiorana, Carlo-
Autor(es): dc.creatorCarvalho, Paulo Sergio Perri de-
Autor(es): dc.creatorOkamoto, Roberta-
Autor(es): dc.creatorSouza, Francisley Ávila-
Data de aceite: dc.date.accessioned2025-08-21T15:34:16Z-
Data de disponibilização: dc.date.available2025-08-21T15:34:16Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/biology13070471-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308105-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308105-
Descrição: dc.descriptionThis study evaluated the bone incorporation process of a screw-shaped internal fixation device made of poly (L-lactide-co-D, L-lactide) (PLDLLA). Thirty-two male Wistar rats received 32 fixation devices (2 mm × 6 mm) randomly assigned to either the right or left tibia and one implant in each animal. After 7, 14, 28, and 42 days, the rats were euthanized and the specimens were subjected to microtomographic computed tomography (microCT) and histomorphometric analyses to evaluate bone interface contact (BIC%) and new bone formation (NBF%) in cortical and cancellous bone areas. The animals euthanized on days 28 and 42 were treated with calcein and alizarin red, and confocal LASER microscopy was performed to determine the mineral apposition rate (MAR). Micro-CT revealed a higher percentage of bone volume (p < 0.006), trabecular separation (p < 0.001), and BIC in the cortical (p < 0.001) and cancellous (p = 0.003) areas at 28 and 42 days than at 7 and 14 days. The cortical NBF at 42 days was greater than that at 7 and 14 days (p = 0.022). No statistically significant differences were observed in cancellous NBF or MAR at 28 and 42 days. Based on these results, it can be seen that the PLDLLA internal fixation device is biocompatible and allows new bone formation around the screw thread.-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Dental Materials and Prothesis School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionImplant Center for Edentulism and Jawbone Atrophies Maxillofacial Surgery and Odontostomatology Unit Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico-
Descrição: dc.descriptionDepartment of Biomedical Surgical and Dental Sciences University of Milan-
Descrição: dc.descriptionImplant Dentistry Postgraduate Program São Leopoldo Mandic School of Dentistry and Research Center, SP-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Dental Materials and Prothesis School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationBiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectabsorbable implants-
Palavras-chave: dc.subjectbone regeneration-
Palavras-chave: dc.subjectbone screws-
Palavras-chave: dc.subjectosseointegration-
Palavras-chave: dc.subjectX-ray microtomography-
Título: dc.titleBone Incorporation of a Poly (L-Lactide-Co-D, L-Lactide) Internal Fixation Device in a Rat’s Tibia: Microtomographic, Confocal LASER, and Histomorphometric Analysis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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