Electroconvulsive therapy for treating patients with agitation and related behavioral disorders due to dementia: a systematic review

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorStella, Florindo-
Autor(es): dc.creatorRadanovic, Márcia-
Autor(es): dc.creatorGallucci-Neto, José-
Autor(es): dc.creatorForlenza, Orestes Vicente-
Data de aceite: dc.date.accessioned2025-08-21T21:43:28Z-
Data de disponibilização: dc.date.available2025-08-21T21:43:28Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/1980-5764-DN-2023-0007-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308090-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308090-
Descrição: dc.descriptionBehavioral disturbances are clinically relevant in patients with dementia, and pharmacological regimens to mitigate these symptoms have provided limited results. Proven to be effective in several psychiatric conditions, electroconvulsive therapy is a potentially beneficial strategy for treating severe agitation due to dementia. Objective: This review aimed to examine the publications on the efficacy, safety and tolerability of electroconvulsive therapy in treating patients with agitation due to dementia. Methods: We performed a systematic analysis on the electroconvulsive therapy to treat patients with dementia and coexisting severe agitation. Articles were classified according to the level of evidence based on methodological design. Patients received an acute course of electroconvulsive therapy, often followed by maintenance intervention. Results: We selected 19 studies (156 patients; 64.1% women; 51–98 years old), which met the inclusion criteria: one case-control study by chart analysis (level of evidence 2); one open-label study (level of evidence 3); three historical/retrospective chart analyses (level of evidence 4); and 14 case series/reports (level of evidence 5). No randomized, sham-controlled clinical trials (level of evidence 1) were identified, which represents the main methodological weakness. Some patients had postictal delirium, cardiovascular decompensation and cognitive changes, lasting for a short time. Conclusions: Overall, patients achieved significant improvement in agitation. However, the main finding of the present review was the absence of methodological design based on randomized and sham-controlled clinical trials. Despite methodological limitations and side effects requiring attention, electroconvulsive therapy was considered a safe and effective treatment of patients with severe agitation and related behavioral disorders due to dementia.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionUniversidade de São Paulo Faculdade de Medicina Instituto de Psiquiatria LIM-27, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista Instituto de Biociências, SP-
Descrição: dc.descriptionUniversidade de São Paulo Faculdade de Medicina Instituto de Psiquiatria Serviço de ECT, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista Instituto de Biociências, SP-
Descrição: dc.descriptionFAPESP: 14/50873-3-
Descrição: dc.descriptionCNPq: 301629/2018-8-
Descrição: dc.descriptionCNPq: 465412/2014-9-
Idioma: dc.languageen-
Relação: dc.relationDementia e Neuropsychologia-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAggression-
Palavras-chave: dc.subjectBehavioral and Psychological Symptoms of Dementia-
Palavras-chave: dc.subjectDementia-
Palavras-chave: dc.subjectElectroconvulsive Therapy-
Título: dc.titleElectroconvulsive therapy for treating patients with agitation and related behavioral disorders due to dementia: a systematic review-
Título: dc.titleEletroconvulsoterapia no tratamento de pacientes com agitação e outros distúrbios de comportamento devido à demência: uma revisão sistemática-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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