The impact of schizophrenia genetic load and heavy cannabis use on the risk of psychotic disorder in the EU-GEI case-control and UK Biobank studies

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Autor(es): dc.contributorKings Coll London-
Autor(es): dc.contributorSouth London & Maudsley NHS Fdn Trust-
Autor(es): dc.contributorIcahn Sch Med Mt Sinai NYC-
Autor(es): dc.contributorWashington Univ-
Autor(es): dc.contributorCardiff Univ-
Autor(es): dc.contributorUniv Bath-
Autor(es): dc.contributorMaastricht Univ-
Autor(es): dc.contributorUniv Palermo-
Autor(es): dc.contributorUniv Cambridge-
Autor(es): dc.contributorRivierduinen Inst Mental Hlth Care-
Autor(es): dc.contributorAzienda Osped Univ Integrata Verona-
Autor(es): dc.contributorAlma Mater Studiorum Univ Bologna-
Autor(es): dc.contributorINSERM-
Autor(es): dc.contributorUniv Complutense-
Autor(es): dc.contributorUniv Oviedo-
Autor(es): dc.contributorUniv Valencia-
Autor(es): dc.contributorComplejo Hosp Univ Santiago de Compostela-
Autor(es): dc.contributorIcahn Sch Med-
Autor(es): dc.contributorUniv Barcelona-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCambridgeshire & Peterborough NHS Fdn Trust-
Autor(es): dc.contributorUCL-
Autor(es): dc.contributorCMP B CHU-
Autor(es): dc.contributorUniv Amsterdam-
Autor(es): dc.contributorASP Crotone-
Autor(es): dc.contributorUniv Paris Est Creteil UPEC-
Autor(es): dc.contributorUniv Utrecht-
Autor(es): dc.contributorUniv Hong Kong-
Autor(es): dc.creatorAustin-Zimmerman, Isabelle-
Autor(es): dc.creatorSpinazzola, Edoardo-
Autor(es): dc.creatorQuattrone, Diego-
Autor(es): dc.creatorWu-Choi, Beatrice-
Autor(es): dc.creatorTrotta, Giulia-
Autor(es): dc.creatorLi, Zhikun-
Autor(es): dc.creatorJohnson, Emma-
Autor(es): dc.creatorRichards, Alexander L.-
Autor(es): dc.creatorFreeman, Tom P.-
Autor(es): dc.creatorTripoli, Giada-
Autor(es): dc.creatorGayer-Anderson, Charlotte-
Autor(es): dc.creatorRodriguez, Victoria-
Autor(es): dc.creatorJongsma, Hannah E.-
Autor(es): dc.creatorFerraro, Laura-
Autor(es): dc.creatorLa Cascia, Caterina-
Autor(es): dc.creatorTosato, Sarah-
Autor(es): dc.creatorTarricone, Ilaria-
Autor(es): dc.creatorBerardi, Domenico-
Autor(es): dc.creatorBonora, Elena-
Autor(es): dc.creatorSeri, Marco-
Autor(es): dc.creatorD'Andrea, Giuseppe-
Autor(es): dc.creatorSzoeke, Andrei-
Autor(es): dc.creatorArango, Celso-
Autor(es): dc.creatorBobes, Julio-
Autor(es): dc.creatorSanjuan, Julio-
Autor(es): dc.creatorSantos, Jose Luis-
Autor(es): dc.creatorArrojo, Manuel-
Autor(es): dc.creatorVelthorst, Eva-
Autor(es): dc.creatorBernardo, Miguel-
Autor(es): dc.creatorDel-Ben, Cristina Marta-
Autor(es): dc.creatorRossi Menezes, Paulo-
Autor(es): dc.creatorSelten, Jean-Paul-
Autor(es): dc.creatorJones, Peter B.-
Autor(es): dc.creatorKirkbride, James B.-
Autor(es): dc.creatorRutten, Bart P. F.-
Autor(es): dc.creatorTortelli, Andrea-
Autor(es): dc.creatorLlorca, Pierre-Michel-
Autor(es): dc.creatorHaan, Lieuwe de-
Autor(es): dc.creatorStilo, Simona-
Autor(es): dc.creatorLa Barbera, Daniele-
Autor(es): dc.creatorLasalvia, Antonio-
Autor(es): dc.creatorSchurnhoff, Franck-
Autor(es): dc.creatorPignon, Baptiste-
Autor(es): dc.creatorvan Os, Jim-
Autor(es): dc.creatorLynskey, Michael-
Autor(es): dc.creatorMorgan, Craig-
Autor(es): dc.creatorO'Donovan, Michael-
Autor(es): dc.creatorLewis, Cathryn M.-
Autor(es): dc.creatorSham, Pak C.-
Autor(es): dc.creatorMurray, Robin M.-
Autor(es): dc.creatorVassos, Evangelos-
Autor(es): dc.creatorDi Forti, Marta-
Autor(es): dc.creatorEU-GEI WP2 Grp-
Data de aceite: dc.date.accessioned2025-08-21T18:47:36Z-
Data de disponibilização: dc.date.available2025-08-21T18:47:36Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-05-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1017/S0033291724002058-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/308068-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/308068-
Descrição: dc.descriptionBackground. The association between cannabis and psychosis is established, but the role of underlying genetics is unclear. We used data from the EU-GEI case-control study and UK Biobank to examine the independent and combined effect of heavy cannabis use and schizophrenia polygenic risk score (PRS) on risk for psychosis. Methods. Genome-wide association study summary statistics from the Psychiatric Genomics Consortium and the Genomic Psychiatry Cohort were used to calculate schizophrenia and cannabis use disorder (CUD) PRS for 1098 participants from the EU-GEI study and 143600 from the UK Biobank. Both datasets had information on cannabis use. Results. In both samples, schizophrenia PRS and cannabis use independently increased risk of psychosis. Schizophrenia PRS was not associated with patterns of cannabis use in the EU-GEI cases or controls or UK Biobank cases. It was associated with lifetime and daily cannabis use among UK Biobank participants without psychosis, but the effect was substantially reduced when CUD PRS was included in the model. In the EU-GEI sample, regular users of high- potency cannabis had the highest odds of being a case independently of schizophrenia PRS (OR daily use high-potency cannabis adjusted for PRS = 5.09, 95% CI 3.08-8.43, p = 3.21 x 10(-10)). We found no evidence of interaction between schizophrenia PRS and patterns of cannabis use. Conclusions. Regular use of high-potency cannabis remains a strong predictor of psychotic disorder independently of schizophrenia PRS, which does not seem to be associated with heavy cannabis use. These are important findings at a time of increasing use and potency of cannabis worldwide.-
Descrição: dc.descriptionEuropean Community's Seventh Framework Programme-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionMedical Research Council (MRC)-
Descrição: dc.descriptionNational Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust-
Descrição: dc.descriptionKing's College London-
Descrição: dc.descriptionNIHR BRC at University College London-
Descrição: dc.descriptionWellcome Trust-
Descrição: dc.descriptionMRC SRF Fellowship-
Descrição: dc.descriptionLord Leverhulme's Charitable Trust-
Descrição: dc.descriptionVelvet Foundation-
Descrição: dc.descriptionSpanish Ministry of Science and Innovation, Instituto de Salud Carlos III (ISCIII)-
Descrição: dc.descriptionEuropean Union, ERDF Funds from the European Commission, ' A way of making Europe' - European Union - NextGenerationEU-
Descrição: dc.descriptionCIBERSAM-
Descrição: dc.descriptionMadrid Regional Government-
Descrição: dc.descriptionEuropean Union Structural Funds-
Descrição: dc.descriptionEuropean Union Seventh Framework Program-
Descrição: dc.descriptionEuropean Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking: Project PRISM-2-
Descrição: dc.descriptionEuropean Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking: Project AIMS-2-TRIALS-
Descrição: dc.descriptionHorizon Europe-
Descrição: dc.descriptionNational Institute of Mental Health of the National Institutes of Health-
Descrição: dc.descriptionFundacion Familia Alonso-
Descrição: dc.descriptionFundacion Alicia Koplowitz-
Descrição: dc.descriptionKings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London SE5 8AF, England-
Descrição: dc.descriptionSouth London & Maudsley NHS Fdn Trust, London, England-
Descrição: dc.descriptionKings Coll London, Inst Psychiat, Dept Psychosis Studies, Crespigny Pk,Denmark Hill, London SE5 8AF, England-
Descrição: dc.descriptionIcahn Sch Med Mt Sinai NYC, Genet & Genom Sci, New York, NY USA-
Descrição: dc.descriptionWashington Univ, Sch Med, Dept Psychiat, St. Louis, MO USA-
Descrição: dc.descriptionCardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Div Psychol Med & Clin Neurosci, Cardiff, Wales-
Descrição: dc.descriptionUniv Bath, Addict & Mental Hlth Grp AIM, Dept Psychol, Bath, England-
Descrição: dc.descriptionMaastricht Univ, Med Ctr, South Limburg Mental Hlth Res & Teaching Network, Sch Mental Hlth & Neurosci,Dept Psychiat & Neurop, POB 616, NL-6200 MD Maastricht, Netherlands-
Descrição: dc.descriptionUniv Palermo, Palermo, Italy-
Descrição: dc.descriptionKings Coll London, Dept Hlth Serv & Populat Res, Inst Psychiat Psychol & Neurosci, ESRC Ctr Soc & Mental Hlth & Hlth Serv, De Crespigny Pk,Denmark Hill, London SE5 8AF, England-
Descrição: dc.descriptionKings Coll London, Inst Psychiat, Populat Res Dept, London, England-
Descrição: dc.descriptionUniv Cambridge, Cambridge CB2 0SZ, England-
Descrição: dc.descriptionRivierduinen Inst Mental Hlth Care, Noordwijk, Netherlands-
Descrição: dc.descriptionAzienda Osped Univ Integrata Verona, Sect Psychiat, Verona, Italy-
Descrição: dc.descriptionAlma Mater Studiorum Univ Bologna, DIENCA, Bologna, Italy-
Descrição: dc.descriptionINSERM, Equipe 15, 51 Ave Marechal Lattre Tassigny, F-94010 Creteil, France-
Descrição: dc.descriptionUniv Complutense, Inst Psychiat & Mental Hlth, Hosp Gen Univ Gregorio Maranon, CIBERSAM,IiSGM,Sch Med, Madrid, Spain-
Descrição: dc.descriptionUniv Oviedo, Ctr Invest Biomed Red Salud Mental CIBERSAM, Sch Med, Psychiat Area,Dept Med, C Julian Claveria s-n, Oviedo 33006, Spain-
Descrição: dc.descriptionUniv Valencia, CIBERSAM, Sch Med, Valencia, Spain-
Descrição: dc.descriptionComplejo Hosp Univ Santiago de Compostela, Inst Invest Sanitaria Santiago de Compostela, Dept Psychiat, Psychiat Genet Grp, Santiago De Compostela, Spain-
Descrição: dc.descriptionIcahn Sch Med, Mt Sinai Sch Med, New York, NY USA-
Descrição: dc.descriptionUniv Barcelona, Barcelona Clin Schizophrenia Unit, IDIBAPS, CIBERSAM,Hosp Clin,Neurosci Inst,Dept Med, Barcelona, Spain-
Descrição: dc.descriptionUniv Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav, Div Psychiat, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Sao Paulo, Brazil-
Descrição: dc.descriptionCambridgeshire & Peterborough NHS Fdn Trust, CAMEO Early Intervent Serv, Cambridge CB21 5EF, England-
Descrição: dc.descriptionUCL, London, England-
Descrição: dc.descriptionCMP B CHU, BP 69, F-63003 Clermont Ferrand 1, France-
Descrição: dc.descriptionUniv Amsterdam, Acad Med Ctr, Dept Psychiat, Early Psychosis Sect, Meibergdreef 5, NL-1105 AZ Amsterdam, Netherlands-
Descrição: dc.descriptionASP Crotone, Dept Mental Hlth & Addict Serv, Crotone, Italy-
Descrição: dc.descriptionUniv Paris Est Creteil UPEC, Hop Univ H Mondor, AP HP, DMU IMPACT,IMRB,Translat Neuropsychiat,Fdn Fonda, F-94010 Creteil, France-
Descrição: dc.descriptionUniv Utrecht, Brain Ctr Rudolf Magnus, Med Ctr, Utrecht, Netherlands-
Descrição: dc.descriptionKings Coll London, Inst Psychiat, London SE5 8AF, England-
Descrição: dc.descriptionSouth London & Maudsley NHS Fdn Trust, Natl Inst Hlth Res NIHR, Mental Hlth Biomed Res Ctr, London, England-
Descrição: dc.descriptionUniv Hong Kong, Dept Psychiat, Hong Kong, Peoples R China-
Descrição: dc.descriptionUniv Hong Kong, Li Kashing Fac Med, Sch Biomed Sci, Hong Kong, Peoples R China-
Descrição: dc.descriptionUniv Estadual Paulista, Sao Paulo, Brazil-
Descrição: dc.descriptionEuropean Community's Seventh Framework Programme: HEALTH-F2-2009-241909-
Descrição: dc.descriptionFAPESP: 2012/0417-0-
Descrição: dc.descriptionWellcome Trust: 101272/Z/12/Z-
Descrição: dc.descriptionMRC SRF Fellowship: MRC MR/T007818/1-
Descrição: dc.descriptionMedical Research Council (MRC): MR/T007818/1-
Descrição: dc.descriptionEuropean Union, ERDF Funds from the European Commission, ' A way of making Europe' - European Union - NextGenerationEU: PMP21/00051-
Descrição: dc.descriptionEuropean Union, ERDF Funds from the European Commission, ' A way of making Europe' - European Union - NextGenerationEU: PI19/01024-
Descrição: dc.descriptionMadrid Regional Government: B2017/BMD-3740 AGES-CM-2-
Descrição: dc.descriptionEuropean Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking: Project PRISM-2: 101034377-
Descrição: dc.descriptionEuropean Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking: Project AIMS-2-TRIALS: 777394-
Descrição: dc.descriptionNational Institute of Mental Health of the National Institutes of Health: 1U01MH124639-01-
Descrição: dc.descriptionNational Institute of Mental Health of the National Institutes of Health: 5P50MH115846-03-
Formato: dc.format4160-4172-
Idioma: dc.languageen-
Publicador: dc.publisherCambridge Univ Press-
Relação: dc.relationPsychological Medicine-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectcannabis-
Palavras-chave: dc.subjectfirst-episode psychosis-
Palavras-chave: dc.subjecthigh-potency cannabis-
Palavras-chave: dc.subjectpolygenic risk score-
Palavras-chave: dc.subjectpsychosis-
Palavras-chave: dc.subjectschizophrenia-
Título: dc.titleThe impact of schizophrenia genetic load and heavy cannabis use on the risk of psychotic disorder in the EU-GEI case-control and UK Biobank studies-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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