Calreticulin Expression in Human Carcinomas: A Systematic Review and Meta-Analysis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPalacon, Mariana Paravani-
Autor(es): dc.creatorFerrisse, Tulio Morandin-
Autor(es): dc.creatorde Oliveira Barbeiro, Camila-
Autor(es): dc.creatorMassucato, Elaine Maria Sgavioli-
Autor(es): dc.creatorBufalino, Andreia-
Data de aceite: dc.date.accessioned2025-08-21T22:26:06Z-
Data de disponibilização: dc.date.available2025-08-21T22:26:06Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.31557/APJCP.2023.24.9.2929-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307979-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307979-
Descrição: dc.descriptionObjective: The present study performed a systematic review and meta-analysis of observational studies on whether calreticulin levels could represent a prognostic factor in carcinoma patients. Calreticulin (CRT) is a multifunctional protein in the endoplasmic reticulum that can play distinct roles in different cancers. Methods: The search was performed in PubMed, Scopus, the Cochrane Library, Web of Science, Lilacs, Science Direct, Embase, Bireme, and SciELO databases. After a full-text evaluation, only 14 articles remained. The RoBANS tool assessed the risk of bias. The metaanalysis was performed with R software, and the odds ratio (OR) was the effect measure. The random effects model was chosen, and the quality of evidence was evaluated according to GRADE. Result: The most frequent carcinomas were in the breasts and the colon. CRT expression varied according to carcinoma origin and type, but these diseases had a prevalence of high CRT levels, indicating tumor progression. The high CRT levels were associated with lymph node metastasis (OR = 3.06 [1.71; 5.48]/p = 0.0002/I2 = 0%). All included articles had a blinding bias. Conclusion: High CRT levels may represent a prognostic factor for metastatic lymph nodes in carcinoma patients.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University (UNESP) School of Dentistry, São Paulo-
Descrição: dc.descriptionDepartment of Dental Prothesis São Paulo State University (UNESP) School of Dentistry, São Paulo-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University (UNESP) School of Dentistry, São Paulo-
Descrição: dc.descriptionDepartment of Dental Prothesis São Paulo State University (UNESP) School of Dentistry, São Paulo-
Descrição: dc.descriptionCNPq: 423945/2016-5-
Formato: dc.format2929-2940-
Idioma: dc.languageen-
Relação: dc.relationAsian Pacific Journal of Cancer Prevention-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCalreticulin-
Palavras-chave: dc.subjectcarcinoma-
Palavras-chave: dc.subjectneoplasms-
Palavras-chave: dc.subjectprognosis-
Palavras-chave: dc.subjectsystematic review-
Título: dc.titleCalreticulin Expression in Human Carcinomas: A Systematic Review and Meta-Analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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