Effectiveness of Local Use of Green Propolis-Loaded Lipid Nanoparticles as Adjuvant Therapy to Scaling and Root Planing in the Management of Periodontitis in Rats Treated with Zoledronate

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorMarília Medical School (FAMEMA)-
Autor(es): dc.contributorJames Cook University-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorLatin American Institute of Dental Research and Education (ILAPEO)-
Autor(es): dc.creatorSilveira, Glauco Rodrigues Carmo-
Autor(es): dc.creatorGanzaroli, Vinícius Franzão-
Autor(es): dc.creatorToro, Luan Felipe-
Autor(es): dc.creatorLopes-Pereira, Estevão-
Autor(es): dc.creatorCosta, Leandro Lemes da-
Autor(es): dc.creatorMello-Neto, João Martins de-
Autor(es): dc.creatorBuchaim, Rogério Leone-
Autor(es): dc.creatorGarcia, Valdir Gouveia-
Autor(es): dc.creatorTheodoro, Leticia Helena-
Autor(es): dc.creatorSforcin, José Maurício-
Autor(es): dc.creatorMarcato, Priscyla Daniely-
Autor(es): dc.creatorErvolino, Edilson-
Data de aceite: dc.date.accessioned2025-08-21T15:14:03Z-
Data de disponibilização: dc.date.available2025-08-21T15:14:03Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms252212443-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307934-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307934-
Descrição: dc.descriptionThis study assessed the effectiveness of the local use of green propolis-loaded lipid nanoparticles (GPlnp) as an adjuvant therapy to scaling and root planing (SRP) to manage experimental periodontitis (EP) in ovariectomized rats treated with zoledronate. Ten weeks before the experiment, 48 female rats were ovariectomized. On day 0, a ligature was installed in the lower first molar to induce EP. From day 0 to day 42, half of the rats were treated with vehicle (VEH), while the other half were treated with 100μg/Kg of zoledronate (ZOL). On day 14, the rats were allocated into the following groups: VEH-NLT, VEH-SRP, VEH-SRP-GPlnp, ZOL-NLT, ZOL-SRP, and ZOL-SRP-GPlnp. VEH-NLT and ZOL-NLT received no local treatment. VEH-SRP and ZOL-SRP received SRP and irrigation with physiological saline solution. VEH-SRP-GPlnp and ZOL-SRP-GPlnp received SRP and irrigation with GPlnp. A single SRP session was carried out, and four irrigation sessions were conducted (on days 14, 16, 18, and 20). On day 42, all animals were euthanized. The hemimandibles were processed for histological, histometric (percentage of total bone tissue (PTBT) and non-vital bone tissue (PNVBT)) and immunohistochemical (TNFα, IL-1β, and TRAP) analysis. VEH-SRP-GPlnp showed better tissue repair, higher PTBT, and lower immunolabeling for TNFα and IL-1β compared to the groups treated with VEH. ZOL-SRP-GPlnp showed a favorable tissue repair, with lower PNVBT, less local inflammation, and lower immunolabeling for TNFα and IL-1β compared to the groups treated with ZOL. Irrigation with GPlnp proved to be effective as an adjuvant therapy to SRP in treating EP in ovariectomized rats treated with zoledronate.-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Diagnostic and Surgery School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionMarília Medical School (FAMEMA), SP-
Descrição: dc.descriptionCollege of Medicine and Dentistry James Cook University-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry University of São Paulo (USP), SP-
Descrição: dc.descriptionLatin American Institute of Dental Research and Education (ILAPEO), PR-
Descrição: dc.descriptionDepartment of Pharmaceutical Sciences School of Pharmaceutical Sciences University of São Paulo (USP), SP-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Diagnostic and Surgery School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectnanoparticles-
Palavras-chave: dc.subjectperiodontitis-
Palavras-chave: dc.subjectpropolis-
Palavras-chave: dc.subjectscaling and root planing-
Palavras-chave: dc.subjectzoledronate-
Título: dc.titleEffectiveness of Local Use of Green Propolis-Loaded Lipid Nanoparticles as Adjuvant Therapy to Scaling and Root Planing in the Management of Periodontitis in Rats Treated with Zoledronate-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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