Maternal malnutrition associated with postnatal sugar consumption increases inflammatory response and prostate disorders in rat offspring

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFox Chase Cancer Center-
Autor(es): dc.contributorInstituto Nacional de Ciencias Médicas y Nutrición-
Autor(es): dc.contributorUniversidad Nacional Autónoma de México-
Autor(es): dc.creatorNaia Fioretto, Matheus-
Autor(es): dc.creatorColombelli, Ketlin Thassiani-
Autor(es): dc.creatorda Silva, Cecilia Luvizutti Ferreira-
Autor(es): dc.creatordos Santos, Sérgio Alexandre Alcantara-
Autor(es): dc.creatorCamargo, Ana Carolina Lima-
Autor(es): dc.creatorConstantino, Flávia Bessi-
Autor(es): dc.creatorPortela, Luiz Marcos Frediani-
Autor(es): dc.creatorAquino, Ariana Musa de-
Autor(es): dc.creatorBarata, Luisa Annibal-
Autor(es): dc.creatorMattos, Renato-
Autor(es): dc.creatorScarano, Wellerson Rodrigo-
Autor(es): dc.creatorZambrano, Elena-
Autor(es): dc.creatorJustulin, Luis Antonio-
Data de aceite: dc.date.accessioned2025-08-21T22:06:53Z-
Data de disponibilização: dc.date.available2025-08-21T22:06:53Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.mce.2024.112223-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307887-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307887-
Descrição: dc.descriptionMaternal malnutrition can alter developmental biology, programming health and disease in offspring. The increase in sugar consumption during the peripubertal period, a worldwide concern, also affects health through adulthood. Studies have shown that maternal exposure to a low protein diet (LPD) is associated with an increase in prostate disease with aging. However, the combined effects of maternal LPD and early postnatal sugar consumption on offspring prostate disorders were not investigated. The effects on aging were evaluated using a maternal gestational model with lactational LPD (6% protein) and sugar consumption (10%) from postnatal day (PND) 21–90, associating the consequences on ventral prostate (VP) rats morphophysiology on PND540. An increase was shown in mast cells and in the VP of the CTR + SUG and Gestational and Lactational Low Protein (GLLP) groups. In GLLP + SUG, a significant increase was shown in TGF-β1 expression in both the systemic and intra-prostatic forms, and SMAD2/3p had increased. The study identified maternal LPD and sugar consumption as risk factors for prostatic homeostasis in senility, activating the TGFβ1-SMAD2/3 pathway, a signaling pathway with potential markers for prostatic disorders.-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University, SP-
Descrição: dc.descriptionCancer Signaling and Epigenetics Program Fox Chase Cancer Center-
Descrição: dc.descriptionDepartamento de Biología de la Reproducción Instituto Nacional de Ciencias Médicas y Nutrición-
Descrição: dc.descriptionFacultad de Química Universidad Nacional Autónoma de México-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University, SP-
Idioma: dc.languageen-
Relação: dc.relationMolecular and Cellular Endocrinology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectMaternal malnutrition-
Palavras-chave: dc.subjectProstate disorders-
Palavras-chave: dc.subjectSugar-
Palavras-chave: dc.subjectTGFβ1-SMAD2/3-
Título: dc.titleMaternal malnutrition associated with postnatal sugar consumption increases inflammatory response and prostate disorders in rat offspring-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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