Maternal protein restriction impairs intestinal morphophysiology and antioxidant system in young male offspring rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFox Chase Cancer Center-
Autor(es): dc.creatordos Santos, Isabela Baptista Leal-
Autor(es): dc.creatorFioretto, Matheus Naia-
Autor(es): dc.creatorJorge, Miguel Silingardi-
Autor(es): dc.creatorBarata, Luísa Annibal-
Autor(es): dc.creatorRibeiro, Isabelle Tenori-
Autor(es): dc.creatorFranzolin, André Matheus Leandro-
Autor(es): dc.creatorStoppa, Erick Guilherme-
Autor(es): dc.creatorMattos, Renato-
Autor(es): dc.creatorPortela, Luiz Marcos Frediane-
Autor(es): dc.creatorEmílio Silva, Maycon Tavares-
Autor(es): dc.creatordos Santos, Sérgio Alexandre Alcântara-
Autor(es): dc.creatorde Arruda Miranda, José Ricardo-
Autor(es): dc.creatorHiruma Lima, Clélia Akiko-
Autor(es): dc.creatorJustulin, Luis Antonio-
Data de aceite: dc.date.accessioned2025-08-21T17:17:52Z-
Data de disponibilização: dc.date.available2025-08-21T17:17:52Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.yexcr.2025.114464-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307861-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307861-
Descrição: dc.descriptionThe developmental origins of health and disease (DOHaD) concept suggests that adverse conditions during gestation can influence the development and function of multiple organs, including the gastrointestinal tract. Maternal protein restriction (MPR) exposure has been associated with negative effects on reproduction, the endocrine system, and liver metabolic health. However, limited research has explored the impact of MPR on the offspring's intestinal morphophysiology. This study investigated the effects of gestational and lactational MPR on the duodenum and colon of young male offspring rats at postnatal (PND)21. We hypothesize that MPR affects intestinal morphophysiology and development early in life. Our findings revealed tachygastria in offspring exposed to MPR. The ultrastructural analysis uncovered a reduction in goblet cell numbers and changes in collagen deposition in the duodenum and colon. We also identified imbalances in inflammatory markers (IL-6 and TGF-β1) and antioxidant enzymes (CAT and SOD). These results demonstrate that MPR significantly affects gastrointestinal morphophysiology early in life by disrupting gastric motility and altering duodenal and colonic histoarchitecture, antioxidant defense, and inflammatory pathways. Such alterations may predispose the descendants to long-term gastrointestinal disorders, underscoring the importance of further research on the developmental origins of intestinal health and disease.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionMarine National Facility-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University, SP-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences Sao Paulo State University, SP-
Descrição: dc.descriptionCancer Signaling and Epigenetics Program Fox Chase Cancer Center-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University, SP-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences Sao Paulo State University, SP-
Idioma: dc.languageen-
Relação: dc.relationExperimental Cell Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDOHaD-
Palavras-chave: dc.subjectEarly life-
Palavras-chave: dc.subjectGastrointestinal disorders-
Palavras-chave: dc.subjectIntestine-
Palavras-chave: dc.subjectMaternal malnutrition-
Título: dc.titleMaternal protein restriction impairs intestinal morphophysiology and antioxidant system in young male offspring rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.