Deoxynivalenol induces ovarian apoptosis in peripubertal rats

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Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.contributorUEL-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorGerez, Juliana Rubira-
Autor(es): dc.creatorde Lemos, Gisele Augusta Amorim-
Autor(es): dc.creatorCamacho, Thaynara-
Autor(es): dc.creatorMarutani, Victor Hugo Brunaldi-
Autor(es): dc.creatorChuffa, Luiz Gustavo-
Autor(es): dc.creatorSilveira, Henrique Spaulonci-
Autor(es): dc.creatorVerri, Waldiceu Aparecido-
Autor(es): dc.creatorda Gloria, Eduardo Micotti-
Autor(es): dc.creatorBracarense, Ana Paula Frederico Rodrigues Loureiro-
Data de aceite: dc.date.accessioned2025-08-21T19:10:23Z-
Data de disponibilização: dc.date.available2025-08-21T19:10:23Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.5433/1679-0359.2023v44n5p1621-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307767-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307767-
Descrição: dc.descriptionPuberty, governed by the endocrine system, marks the onset of reproductive functions in animals and humans through a series of physiological and biological transformations. Although the mycotoxin DON can disrupt hormonal balance and cause reproductive abnormalities, its impact on puberty-associated reproductive changes remains understudied. Considering the increased exposure of children and adolescents to DON, our study aimed to elucidate its influence on follicular integrity and the expression of pro-apoptotic proteins (BAX and Caspase-3) and anti-apoptotic protein (BCL-2) in juvenile rat ovarian tissue. We divided ten 28-day-old prepubertal Wistar rats into two dietary groups for 28 days: a control group with a mycotoxin-free diet and a DON group with a diet containing 10 mg DON/Kg. After the experiment, ovaries and uterus weights were recorded, and the ovaries underwent morphometric and immunohistochemical analysis. DON exposure led to significant reductions in both ovarian and uterine weights. Although DON intake did not change the number of ovarian follicles across developmental stages, we observed an increased expression of BAX and Caspase-3 and a decreased BCL-2 expression in most follicular stages and corpora lutea. In summary, DON exposure during puberty can interfere with apoptotic processes in diverse ovarian cell populations during early adulthood.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionProfas Dras Laboratory of Animal Pathology Department of Preventive Veterinary Medicine Universidade Estadual de Londrina UEL, PR-
Descrição: dc.descriptionUEL, PR-
Descrição: dc.descriptionVeterinary Medecine UEL, PR-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Universidade Estadual Paulista UNESP, SP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology UNESP, SP-
Descrição: dc.descriptionLaboratory of Pain Inflammation Neuropathy and Cancer Department of Pathological Sciences UEL, PR-
Descrição: dc.descriptionLaboratory of Mycology Universidade de São Paulo USP, SP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Universidade Estadual Paulista UNESP, SP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology UNESP, SP-
Descrição: dc.descriptionCAPES: 0389/2019-
Descrição: dc.descriptionCNPq: 403843/2021-9-
Formato: dc.format1621-1636-
Idioma: dc.languageen-
Relação: dc.relationSemina:Ciencias Agrarias-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectApoptosis-
Palavras-chave: dc.subjectDeoxynivalenol-
Palavras-chave: dc.subjectFollicular integrity-
Palavras-chave: dc.subjectOvary-
Palavras-chave: dc.subjectRat-
Título: dc.titleDeoxynivalenol induces ovarian apoptosis in peripubertal rats-
Título: dc.titleDesoxinivalenol durante período pré-puberal induz apoptose em ovários de ratas imaturas-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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