Development of an Electrochemical Paper-Based Device Modified with Functionalized Biochar for the Screening of Paracetamol in Substandard Medicines

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of California-
Autor(es): dc.creatorSilva, Martin Kassio Leme da-
Autor(es): dc.creatorBarreto, Francisco Contini-
Autor(es): dc.creatorSousa, Guilherme dos Santos-
Autor(es): dc.creatorSimões, Rafael Plana-
Autor(es): dc.creatorAhuja, Gaurav-
Autor(es): dc.creatorDutta, Samriddha-
Autor(es): dc.creatorMulchandani, Ashok-
Autor(es): dc.creatorCesarino, Ivana-
Data de aceite: dc.date.accessioned2025-08-21T15:21:43Z-
Data de disponibilização: dc.date.available2025-08-21T15:21:43Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/molecules29225468-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307754-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307754-
Descrição: dc.descriptionThe global prevalence of counterfeit and low-quality pharmaceuticals poses significant health risks and challenges in medical treatments, creating a need for rapid and reliable drug screening technologies. This study introduces a cost-effective electrochemical paper-based device (ePAD) modified with functionalized bamboo-derived biochar (BCF) for the detection of paracetamol in substandard medicines. The sensor was fabricated using a custom 3D-printed stencil in PLA, designed for efficient production, and a 60:40 (m/m) graphite (GR) and glass varnish (GV) conductive ink, resulting in a robust and sensitive platform. The electroactive area of the ePAD/BCF sensor was determined as 0.37 cm2. Characterization via SEM and cyclic voltammetry (CV) verified its structural and electrochemical stability. The sensor demonstrated linear detection of paracetamol from 5.0 to 60.0 µmol L−1 with a detection limit of 3.50 µmol L−1. Interference studies showed high selectivity, with recoveries of over 90%, and the sensor successfully quantified paracetamol in commercial analgesic and anti-flu samples. This sustainable, bamboo-based ePAD offers a promising solution for rapid on-site pharmaceutical quality control, with significant potential to enhance drug screening accuracy.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSchool of Agriculture São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Chemical and Environmental Engineering University of California-
Descrição: dc.descriptionDepartment of Bioengineering University of California-
Descrição: dc.descriptionSchool of Agriculture São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFAPESP: 2022/03334-6-
Descrição: dc.descriptionFAPESP: 2022/03762-8-
Descrição: dc.descriptionCAPES: 88881.702907/2022-01-
Idioma: dc.languageen-
Relação: dc.relationMolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject3D printing-
Palavras-chave: dc.subjectconductive ink-
Palavras-chave: dc.subjectelectrochemical paper-based analytical devices (ePADs)-
Palavras-chave: dc.subjectparacetamol-
Palavras-chave: dc.subjectsubstandard drugs-
Título: dc.titleDevelopment of an Electrochemical Paper-Based Device Modified with Functionalized Biochar for the Screening of Paracetamol in Substandard Medicines-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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