Adaptive responses of the ileum of NOD mice to low-dose fluoride: A proteomic exploratory study

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorTrevizol, Juliana S.-
Autor(es): dc.creatorBuzalaf, Nathalia R.-
Autor(es): dc.creatorDionizio, Aline-
Autor(es): dc.creatorDelgado, Aislan Q.-
Autor(es): dc.creatorde Lara, João P. Z.-
Autor(es): dc.creatorMagalhães, Ana C.-
Autor(es): dc.creatorBosqueiro, José R.-
Autor(es): dc.creatorBuzalaf, Marília A. R.-
Data de aceite: dc.date.accessioned2025-08-21T22:07:25Z-
Data de disponibilização: dc.date.available2025-08-21T22:07:25Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/cbf.3976-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307703-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307703-
Descrição: dc.descriptionFluoride (F) has been employed worldwide to control dental caries. More recently, it has been suggested that the consumption of low doses of F in the drinking water may reduce blood glucose levels, introducing a new perspective for the use of F for the management of blood glucose. However, the exact mechanism by which F affects blood glucose levels remains largely unexplored. Given that the small gut plays a pivotal role in glucose homeostasis, the aim of this study was to investigate the proteomic changes induced by low doses of F in the ileum of female nonobese-diabetic (NOD) mice. Forty-two female NOD mice were divided into two groups based on the F concentration in their drinking water for 14 weeks: 0 (control) or 10 mgF/L. At the end of the experimental period, the ileum was collected for proteomic and Western blot analyses. Proteomic analysis indicated an increase in isoforms of actin, gastrotropin, several H2B histones, and enzymes involved in antioxidant processes, as well as a decrease in enzymes essential for energy metabolism. In summary, our data indicates an adaptive response of organism to preserve protein synthesis in the ileum, despite significant alterations in energy metabolism typically induced by F, therefore highlighting the safety of controlled fluoridation in water supplies.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry University of São Paulo-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University-
Descrição: dc.descriptionDepartment of Physical Education Faculty of Science São Paulo State University-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University-
Descrição: dc.descriptionDepartment of Physical Education Faculty of Science São Paulo State University-
Descrição: dc.descriptionFAPESP: 2018/00352-8-
Idioma: dc.languageen-
Relação: dc.relationCell Biochemistry and Function-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectdiabetes-
Palavras-chave: dc.subjectepigenetic-
Palavras-chave: dc.subjectfluoride-
Palavras-chave: dc.subjectglucose homeostasis-
Palavras-chave: dc.subjectileum-
Título: dc.titleAdaptive responses of the ileum of NOD mice to low-dose fluoride: A proteomic exploratory study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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