Lemon flavonoids nutraceutical (Eriomin®) attenuates prediabetes intestinal dysbiosis: A double-blind randomized controlled trial

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of California Davis-
Autor(es): dc.contributorUniversity of Illinois at Chicago-
Autor(es): dc.creatorRamos, Fernanda M. M.-
Autor(es): dc.creatorRibeiro, Carolina B.-
Autor(es): dc.creatorCesar, Thais B.-
Autor(es): dc.creatorMilenkovic, Dragan-
Autor(es): dc.creatorCabral, Lucélia-
Autor(es): dc.creatorNoronha, Melline F.-
Autor(es): dc.creatorSivieri, Katia-
Data de aceite: dc.date.accessioned2025-08-21T22:40:23Z-
Data de disponibilização: dc.date.available2025-08-21T22:40:23Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/fsn3.3654-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307681-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307681-
Descrição: dc.descriptionEriocitrin (eriodictyol 7-O-β-rutinoside), a citrus flavonoid from lemon juice and peel, reduces hyperglycemia and improves diabetes-related biomarkers in prediabetes patients. Eriocitrin is first metabolized by gut microbiota, producing energy for gut cells and short chain fatty acids that play a relevant role in glycemic control. The aim of this study was to assess the effect of Eriomin®, a nutraceutical composed of 70% eriocitrin, 5% hesperidin, and 4% naringin, on the microbiota of prediabetic patients. Patients were randomly divided into two groups and received unlabeled capsules of Eriomin® (200 mg/day) or placebo during 12 weeks. After treatment with the nutraceutical, it was a 6% decrease of hyperglycemia and 22% increase of GLP-1 blood levels of (p <.05). The profile of intestinal microorganisms, obtained by 16S rRNA sequencing of the patients' feces extract, showed changes in microbiota composition, such as lower growth of Firmicutes and less abundance of the Lachnospiraceae family. The family Ruminococcaceae increased and Blautia genus reduced with Eriomin® supplementation. In additional, Blautia was positively correlated with hyperglycemia reduction. In conclusion, the nutraceutical Eriomin® moderately reduced the growth of microorganisms associated with intestinal dysbiosis and increased the abundance of beneficial bacteria. Changes promoted mainly by the flavonoid eriocitrin in the microbiota were related to a lower glycemic level and increased production of GLP-1 in patients with prediabetes.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionGraduate Program in Food Nutrition and Food Engineering Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Nutrition University of California Davis-
Descrição: dc.descriptionInstitute of Biosciences Depart of General and Applied Biology São Paulo State University (UNESP)-
Descrição: dc.descriptionResearch Informatics Core Research Resource Center University of Illinois at Chicago-
Descrição: dc.descriptionGraduate Program in Food Nutrition and Food Engineering Sao Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Biosciences Depart of General and Applied Biology São Paulo State University (UNESP)-
Formato: dc.format7283-7295-
Idioma: dc.languageen-
Relação: dc.relationFood Science and Nutrition-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectclinical trial-
Palavras-chave: dc.subjecteriocitrin nutraceutical-
Palavras-chave: dc.subjectEriomin®-
Palavras-chave: dc.subjectintestinal dysbiosis-
Palavras-chave: dc.subjectlemon flavonoid-
Palavras-chave: dc.subjectmicrobiota (16S rRNA)-
Palavras-chave: dc.subjectpre-diabetes-
Título: dc.titleLemon flavonoids nutraceutical (Eriomin®) attenuates prediabetes intestinal dysbiosis: A double-blind randomized controlled trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.