Antiviral Activity of Pd(II) Complexes with Aminoadamantanes Against Arboviruses

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Federal do Tocantins-
Autor(es): dc.contributorAeronautics Technological Institute (ITA)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorDonostia International Physics Center – DIPC-
Autor(es): dc.contributorCNRS-
Autor(es): dc.creatorSilva, Laura Barros-
Autor(es): dc.creatorCruz, Állefe Barbosa-
Autor(es): dc.creatorPereira, Douglas Henrique-
Autor(es): dc.creatorCassani, Natasha Marques-
Autor(es): dc.creatorAquino Ruiz, Uriel Enrique-
Autor(es): dc.creatorSantos, Igor Andrade-
Autor(es): dc.creatorMartins, Daniel Oliveira Silva-
Autor(es): dc.creatorNakahata, Douglas Hideki-
Autor(es): dc.creatorde Alencar Simoni, Déborah-
Autor(es): dc.creatorKanavos, Ioannis-
Autor(es): dc.creatorRonga, Luisa-
Autor(es): dc.creatorLobinski, Ryszard-
Autor(es): dc.creatordos Santos Pereira, Anna Karla-
Autor(es): dc.creatorGomes Jardim, Ana Carolina-
Autor(es): dc.creatorde Paiva, Raphael Enoque Ferraz-
Autor(es): dc.creatorCorbi, Pedro Paulo-
Data de aceite: dc.date.accessioned2025-08-21T15:20:59Z-
Data de disponibilização: dc.date.available2025-08-21T15:20:59Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-04-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/slct.202404225-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307615-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307615-
Descrição: dc.descriptionIn this paper, we report the synthesis, structural characterization, and antiviral properties of palladium(II) complexes with amantadine (atd) and memantine (mtn). Elemental and mass spectrometric analyses indicated a 1:2 metal/ligand ratio. The single crystal data for Pd-mtn revealed that the complex adopts a square geometry with the two memantine ligands bonded to Pd(II) by the nitrogen atoms of the NH2 group, in a trans configuration. Computational studies supported a similar structure for Pd-atd. The complexes were stable in DMSO solution for 24 h. The antiviral properties of Pd-atd and Pd-mtn were evaluated against Zika (ZIKV) and Chikungunya (CHIKV) viruses in vitro at their highest noncytotoxic concentrations. The Pd-atd (at 2 µM) and Pd-mtn (at 10 µM) complexes were able to impair 76% and 96% of CHIKV replication, respectively, which points the coordination of amantadine and memantine to Pd(II) as a successful strategy to increase their anti-CHIKV properties. Conversely, the Pd(II) complexes did not significantly inhibit the replication of ZIKV, which confirms the selectivity towards CHIKV. Interaction of the compounds with N-acetyl-l-cysteine, a model disulfide-containing peptide, and plasmid DNA pointed to Cys-containing peptides as more likely targets than nucleotides for the complexes.-
Descrição: dc.descriptionInstitute of Chemistry University of Campinas – UNICAMP, PO Box 6154, São Paulo-
Descrição: dc.descriptionGraduate Program in Chemistry Universidade Federal do Tocantins, Tocantins-
Descrição: dc.descriptionDepartment of Chemistry Aeronautics Technological Institute (ITA), Praça Marechal Eduardo Gomes, 50, Vila das Acácias, São Paulo-
Descrição: dc.descriptionInstitute of Biomedical Sciences Federal University of Uberlândia, Minas Gerais-
Descrição: dc.descriptionInstitute of Bioscience Language and Exact Sciences São Paulo State University, São Paulo-
Descrição: dc.descriptionDonostia International Physics Center – DIPC, Paseo Manuel de Lardizabal, 4, Gipuzkoa-
Descrição: dc.descriptionInstitut des Sciences Analytiques et de Physico-Chimie Pour l'Environnement et les Matériaux – IPREM Université de Pau et des Pays de l'Adour E2S UPPA CNRS, Nouvelle-Aquitaine-
Descrição: dc.descriptionInstitute of Bioscience Language and Exact Sciences São Paulo State University, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationChemistrySelect-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAmantadine-
Palavras-chave: dc.subjectChikungunya-
Palavras-chave: dc.subjectMemantine-
Palavras-chave: dc.subjectPalladium(II)-
Palavras-chave: dc.subjectZika-
Título: dc.titleAntiviral Activity of Pd(II) Complexes with Aminoadamantanes Against Arboviruses-
Tipo de arquivo: dc.typelivro digital-
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