Pregnancy hypertension-associated endothelial dysfunction is attenuated by isoflurane anesthesia: Evidence of protective effect related to increases in nitric oxide

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Ribeirao Preto (UNAERP)-
Autor(es): dc.creatorRodrigues, Serginara David-
Autor(es): dc.creatorda Silva, Maria Luiza Santos-
Autor(es): dc.creatorMartins, Laisla Zanetoni-
Autor(es): dc.creatorGomes, Sáskia Estela Biasotti-
Autor(es): dc.creatorMariani, Noemia A.P.-
Autor(es): dc.creatorSilva, Erick J.R.-
Autor(es): dc.creatorKushima, Hélio-
Autor(es): dc.creatorMattos, Bruna Rahal-
Autor(es): dc.creatorRizzi, Elen-
Autor(es): dc.creatorDias-Junior, Carlos Alan-
Data de aceite: dc.date.accessioned2025-08-21T18:57:13Z-
Data de disponibilização: dc.date.available2025-08-21T18:57:13Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2023.122039-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307606-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307606-
Descrição: dc.descriptionAims: Pregnancy hypertension-induced endothelial dysfunction associated with impairment of nitric oxide (NO) bioavailability and hemodynamic derangements is a challenging for urgent procedures requiring maternal anesthesia. The volatile anesthetic isoflurane has demonstrated NO-associated protective effects. However, this isoflurane-induced effect is still unclear in pregnancy hypertension. Therefore, the present study examined the potential protective effects of isoflurane anesthesia on endothelial dysfunction and hemodynamic changes induced by hypertensive pregnancy associated with fetal and placental growth restrictions. Materials and methods: Animals were distributed into four groups: normotensive pregnant rats (Preg), anesthetized pregnant rats (Preg+Iso), hypertensive pregnant rats (HTN-Preg), and anesthetized hypertensive pregnant rats (HTN-Preg+Iso). Systolic and diastolic pressures, mean arterial pressure (MAP), heart rate, fetal and placental weights, vascular contraction, endothelium-derived NO-dependent vasodilation, and NO levels were assessed. The vascular endothelial growth factor (VEGF) levels and endothelial NO synthase (eNOS) Serine (1177) phosphorylation (p-eNOS) expression were also examined. Key findings: Isoflurane produced more expressive hypotensive effects in the HTN-Preg+Iso versus Preg+Iso group, with respective reductions in MAP by 50 ± 13 versus 25 ± 4 mmHg (P < 0.05). Also, HTN-Preg+Iso compared to the HTN-Preg group showed (respectively) preventions against the weight loss of the fetuses (4.0 ± 0.6 versus 2.8 ± 0.6 g, P < 0.05) and placentas (0.37 ± 0.06 versus 0.30 ± 0.06 mg, P < 0.05), hyper-reactive vasocontraction response (1.8 ± 0.4 versus 2.8 ± 0.6 g, P < 0.05), impaired endothelium-derived NO-dependent vasodilation (84 ± 8 versus 50 ± 17 %, P < 0.05), reduced VEGF levels (147 ± 46 versus 25 ± 13 pg/mL, P < 0.05), and decreased p-eNOS expression (0.24 ± 0.07 versus 0.09 ± 0.05 arbitrary units, P < 0.05). Significance: Isoflurane anesthesia protects maternal endothelial function in pregnancy hypertension, and possibly endothelium-derived NO is involved.-
Descrição: dc.descriptionASCRS Research Foundation-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences Sao Paulo State University (UNESP), SP-
Descrição: dc.descriptionUnit of Biotechnology University of Ribeirao Preto (UNAERP), SP-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences Sao Paulo State University (UNESP), SP-
Descrição: dc.descriptionASCRS Research Foundation: 2020/03135-8-
Descrição: dc.descriptionASCRS Research Foundation: 2021/03.794-4-
Descrição: dc.descriptionASCRS Research Foundation: 2021/03792-1-
Descrição: dc.descriptionASCRS Research Foundation: 2021/08380-3-
Descrição: dc.descriptionASCRS Research Foundation: 2021/12010-7-
Descrição: dc.descriptionASCRS Research Foundation: 2022/10773-6-
Descrição: dc.descriptionCNPq: 305091/2021-
Descrição: dc.descriptionCNPq: 406442/2022-3-
Idioma: dc.languageen-
Relação: dc.relationLife Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnesthesia-
Palavras-chave: dc.subjectEndothelial dysfunction-
Palavras-chave: dc.subjectGestational hypertension-
Palavras-chave: dc.subjectHemodynamic derangements-
Palavras-chave: dc.subjectIsoflurane-
Palavras-chave: dc.subjectNitric oxide-
Título: dc.titlePregnancy hypertension-associated endothelial dysfunction is attenuated by isoflurane anesthesia: Evidence of protective effect related to increases in nitric oxide-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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