Interleukin 17F Gene Polymorphism as a Potential Protective Factor in the Immunopathology of Ocular Toxoplasmosis

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorFaculty of Medicine of São José do Rio Preto (FAMERP)-
Autor(es): dc.contributorOphthalmology Outpatient Clinic-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorState University of Maringá-
Autor(es): dc.creatorda Silva, Danilo Donizete-
Autor(es): dc.creatorFrederico, Fábio Batista-
Autor(es): dc.creatorPreviato, Mariana-
Autor(es): dc.creatorSiqueira, Rubens Camargo-
Autor(es): dc.creatorBonini-Domingos, Claudia Regina-
Autor(es): dc.creatorde Souza, Victor Hugo-
Autor(es): dc.creatorCastiglioni, Lilian-
Autor(es): dc.creatorBrandão, Cinara Cássia-
Autor(es): dc.creatorde Mattos, Luiz Carlos-
Autor(es): dc.creatorAyo, Christiane Maria-
Data de aceite: dc.date.accessioned2025-08-21T20:07:01Z-
Data de disponibilização: dc.date.available2025-08-21T20:07:01Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/pim.13038-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307563-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307563-
Descrição: dc.descriptionOcular toxoplasmosis (OT) is characterised by intraocular inflammation due to Toxoplasma gondii infection. Studies have found that interleukin 17 (IL-17) plays a central role in the pathology of OT. However, nucleotide variability in IL17 and interleukin 17 receptor (IL17R) genes has not been characterised in OT. As cytokine gene polymorphisms may influence the expression of these molecules, the aim of this study was to verify whether IL17A (rs2275913), IL17F (rs763780), IL17RA (rs4819554) and IL17RC (rs708567) polymorphisms are associated with OT in a Brazilian population. This study enrolled 214 patients seropositive for T. gondii (110 with OT and 104 without) and 107 controls. Polymorphisms were identified by PCR-restriction fragment length polymorphism analysis, validated by DNA sequencing with chi-square and multivariate analyses being used to assess possible associations between polymorphisms and OT. Logistic regression under the dominant model revealed a protection factor against OT of the C mutant allele of the IL17F (rs763780) polymorphism. The T/C-C/C genotypes were significantly more common in patients without OT compared to those with OT (p value = 0.0066) and controls (p value = 0.014). Findings from this study suggest that the IL17F polymorphism may have an influence in the immunopathology of OT in Brazilian individuals.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLaboratory of Immunogenetics Department of Molecular Biology Faculty of Medicine of São José do Rio Preto (FAMERP)-
Descrição: dc.descriptionHospital de Base of the Regional Medical Faculty Foundation (HB-FUNFARME) Ophthalmology Outpatient Clinic-
Descrição: dc.descriptionDepartment of Biology São Paulo State University “Júlio de Mesquita Filho” (UNESP)-
Descrição: dc.descriptionLaboratory of Immunogenetics Department of Basic Health Sciences State University of Maringá-
Descrição: dc.descriptionDepartment of Epidemiology and Collective Health Faculty of Medicine of São José do Rio Preto (FAMERP)-
Descrição: dc.descriptionDepartment of Biology São Paulo State University “Júlio de Mesquita Filho” (UNESP)-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionCNPq: 09/2022-
Descrição: dc.descriptionFAPESP: 2013/06580-9-
Descrição: dc.descriptionFAPESP: 2013/10050-5-
Descrição: dc.descriptionFAPESP: 2013/25650-8-
Idioma: dc.languageen-
Relação: dc.relationParasite Immunology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcytokine-
Palavras-chave: dc.subjectinterleukin 17-
Palavras-chave: dc.subjectocular toxoplasmosis-
Palavras-chave: dc.subjectpolymorphism-
Palavras-chave: dc.subjectToxoplasma gondii-
Título: dc.titleInterleukin 17F Gene Polymorphism as a Potential Protective Factor in the Immunopathology of Ocular Toxoplasmosis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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