Disruptive ecotoxicological effects of fluoxetine on serotoninergic signaling and enteric neurogenesis in early zebrafish larvae (Danio rerio)

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Warmia and Mazury-
Autor(es): dc.contributorTransphamation Poland Ltd.-
Autor(es): dc.creatorFagundes, Kainã Rocha Cabrera-
Autor(es): dc.creatorKasica, Natalia-
Autor(es): dc.creatorPotoczna, Małgorzata-
Autor(es): dc.creatorOkitsu-Sakurayama, Shiho-
Autor(es): dc.creatorPodlasz, Piotr-
Autor(es): dc.creatorde Britto Mari, Renata-
Data de aceite: dc.date.accessioned2025-08-21T18:41:03Z-
Data de disponibilização: dc.date.available2025-08-21T18:41:03Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.etap.2025.104698-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307540-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307540-
Descrição: dc.descriptionThis study investigated the multilevel effects of environmentally relevant concentrations of fluoxetine on serotonergic signaling and enteric neurogenesis in early zebrafish larvae (Danio rerio). To this end, zebrafish were exposed to various concentrations of fluoxetine for four days, from the 1,000-cell stage to 4 days post-fertilization (dpf).Following exposure, whole larvae were subjected to molecular, morphological, and behavioral analyses. All tested concentrations led to upregulation of the serotonin transporter (slc6a4a). At intermediate concentrations, overexpression of the serotonin receptor htr1aa was observed. The highest concentration caused a reduced total enteric neurons density, while the intermediate concentration reduced the density of serotonergic enteric neurons. Additionally, the highest concentration decreased larval locomotion and impaired their ability to differentiate between light and dark phases.Across all tested concentrations, fluoxetine disrupted serotonergic signaling, impaired enteric neurogenesis, and induced sedative-like behavioral effects.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionLaboratory of Animal Morphophysiology Biosciences Institute Sao Paulo State University, Praça Infante Dom Henrique, s/n, SP-
Descrição: dc.descriptionDepartment of Animal Anatomy Faculty of Veterinary Medicine University of Warmia and Mazury-
Descrição: dc.descriptionDepartment of Pathophysiology Forensic Veterinary Medicine and Administration Faculty of Veterinary Medicine University of Warmia and Mazury-
Descrição: dc.descriptionTransphamation Poland Ltd.-
Descrição: dc.descriptionLaboratory of Animal Morphophysiology Biosciences Institute Sao Paulo State University, Praça Infante Dom Henrique, s/n, SP-
Descrição: dc.descriptionCAPES: 88881.690279/2022-01-
Descrição: dc.descriptionCAPES: 88887.670017/2022-00-
Idioma: dc.languageen-
Relação: dc.relationEnvironmental Toxicology and Pharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEmbryogenesis-
Palavras-chave: dc.subjectEmergent contaminats-
Palavras-chave: dc.subjectEnteric nervous system-
Palavras-chave: dc.subjectGut-brain axis-
Palavras-chave: dc.subjectSerotoninergic system-
Palavras-chave: dc.subjectSSRIs-
Título: dc.titleDisruptive ecotoxicological effects of fluoxetine on serotoninergic signaling and enteric neurogenesis in early zebrafish larvae (Danio rerio)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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