Effect of Different Desensitizing Protocols on Pulp Inflammatory Responses in Whitened Teeth: A Randomized Clinical Trial

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal do Pará (UFPA)-
Autor(es): dc.creatorBarros, Antonia Patricia Oliveira-
Autor(es): dc.creatorde Mendonça, Raissa Pinheiro-
Autor(es): dc.creatorAlencar, Cristiane de Melo-
Autor(es): dc.creatorPinheiro, João de Jesus Viana-
Autor(es): dc.creatorRothbarth, Cláudia Pires-
Autor(es): dc.creatorJúnior, Sérgio de Melo Alves-
Autor(es): dc.creatorSilva, Cecy Martins-
Data de aceite: dc.date.accessioned2025-08-21T19:02:38Z-
Data de disponibilização: dc.date.available2025-08-21T19:02:38Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2174/18742106-v17-230619-2022-117-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307508-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307508-
Descrição: dc.descriptionPurpose: This randomized controlled, blind clinical trial evaluated the efficacy of different desensitizing protocols in preventing pulp inflammation after whitening treatment with hydrogen peroxide (HP) at 35% (Whiteness HP 35%). Materials and Methods: Thirty healthy third human molars extracted by orthodontic indication were randomized and allocated into five groups (n=5): NC (negative control): without intervention; PC (positive control): HP; PBM: HP + photobiomodulation with a Watts LASER; CPP: HP + casein phosphopeptide amorphous calcium phosphopeptide (CPP-ACP); and NANO: HP + nano-hydroxyapatite. The in-office whitening was performed in two sessions with a single 45 minutes application at an interval of 48 hours. Pulp tissues were extirpated for immunohistochemical analysis. Immunoreaction for activated caspase-3 was observed, and images were acquired using an Axio Scope A1 microscope. The Kruskal-Wallis test was used to evaluate the immunoexpression of caspase-3. Results: Comparisons between the PC and NC groups revealed a statistically significant difference (p<0.05) for the analysis of caspase-3 immunoexpression. A statistically significant difference (p<0.05) was also observed for the CPP and PBM groups in relation to the PC. Conclusion: Photobiomodulation and CPP-ACP are promising alternatives to minimize pulpal inflammation induced by tooth whitening. Clinical Trial Registration Number: NCT04548674.-
Descrição: dc.descriptionUniversidade Federal do Pará-
Descrição: dc.descriptionDepartment of Restorative Dentistry São Paulo State University, SP-
Descrição: dc.descriptionDepartment of Pathology and Immunohistochemistry Faculty of Dentistry Federal University of Pará, PA-
Descrição: dc.descriptionDepartment of Dental Materials of the Graduate Program in Dentistry Federal University of Pará, PA-
Descrição: dc.descriptionDepartment of Restorative Dentistry São Paulo State University, SP-
Descrição: dc.descriptionUniversidade Federal do Pará: 161846/2018-1-
Idioma: dc.languageen-
Relação: dc.relationOpen Dentistry Journal-
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Palavras-chave: dc.subjectCaspase-3-
Palavras-chave: dc.subjectImmunohistochemistry-
Palavras-chave: dc.subjectRandomized controlled clinical trial-
Palavras-chave: dc.subjectSensitivity-
Palavras-chave: dc.subjectTherapies-
Palavras-chave: dc.subjectTooth whitening-
Título: dc.titleEffect of Different Desensitizing Protocols on Pulp Inflammatory Responses in Whitened Teeth: A Randomized Clinical Trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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