Effect of treatment with phosphate, casein phosphopeptide and fluoride on the remineralization: in vitro study

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorSchool of Dentistry-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorAnn and Robert Lurie Children’s Hospital-
Autor(es): dc.creatorde OLIVEIRA, Marília Andrade Figueiredo-
Autor(es): dc.creatorGONÇALVES, Francyenne Maira Castro-
Autor(es): dc.creatorDELBEM, Alberto Carlos Botazzo-
Autor(es): dc.creatorFERNANDES, Gabriela Leal Peres-
Autor(es): dc.creatorCANNON, Mark L.-
Autor(es): dc.creatorDANELON, Marcelle-
Data de aceite: dc.date.accessioned2025-08-21T17:11:04Z-
Data de disponibilização: dc.date.available2025-08-21T17:11:04Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/1807-3107bor-2024.vol38.0036-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307456-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307456-
Descrição: dc.descriptionThis study aimed to evaluate in vitro the effect protocols and anticaries agents containing casein amorphous calcium fluoride phosphopeptide-phosphate (CPP-ACPF, MI Paste Plus), sodium trimetaphosphate (TMP) and fluoride (F), in remineralization of caries lesions. Bovine enamel blocks with initial caries lesions were divided into groups (n = 12): 1) Toothpaste without F-TMP-MI Plus (Placebo); 2) Toothpaste 1100 ppm F (1100F), 3) 1100F + MI Paste Plus (1100F-MI Paste Plus), 4) Toothpaste with 1100F + Neutral gel with 4,500 ppm F + 5%TMP (1100F + Gel TMP) and 5) Toothpaste with 1100F + Neutral gel with 9,000 ppm F (1100F + Gel F). For the 4 and 5 groups the gel was applied only once for 1 minute, initially to the study. For the 3 group, after treatment with 1100F, MI Paste Plus was applied 2x/day for 3 minute. After pH cycling, the percentage of surface hardness recovery (%SHR); integrated loss of subsurface hardness (ΔKHN); profile and depth of the subsuperficial lesion (PLM); concentrations of F, calcium (Ca) and phosphorus (P) in enamel was determined. The data were analyzed by ANOVA (1-criterion) and Student-Newman-Keuls test (p < 0.001). Treatment with 1100F alone led to ~ 28% higher remineralization when compared to treatment with 1100F associated with MI Paste Plus (p < 0.001). The 1100F and 1100F + Gel F groups showed similar values for %SHR (p = 0.150). 1100F + Gel TMP treatment also remineralized the enamel surface by ~ 30% and 20% when compared to the 1100F + Gel F and 1100F groups (p < 0.001). The lower lesion depth (AKHN) was observed for the 1100F + Gel TMP group (p < 0.001), where it was 54% and 44% lower in comparison to the 1100F and 1100F + Gel F groups (p < 0.001). Polarized light microscopy photomicrographs showed subsurface lesions in all groups, but these lesions were present to a lower extent in the 1100F + Gel TMP group (p < 0.001). Treatment with 1100F + Gel TMP promoted an increase in the concentration of Ca in the enamel by ~ 57% and ~ 26% when compared to the 1100F and 1100F + MI Paste Plus groups (p < 0.001), respectively. There were no significant differences between the 1100F, 1100F + MI Paste Plus and 1100F + Gel F groups (p > 0.001). Similar values of P in the enamel were observed in the 1100F, 1100F + MI Paste Plus and 1100F + Gel F groups (p > 0.001), except for the 1100F + Gel TMP group, which presented a high concentration (p < 0.001). We conclude that the 1100F+TMP gel treatment/protocol led to a significant increased remineralization when compared to the other treatments/protocols and may be a promising strategy for patients with early caries lesions.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniversidade de Ribeirão Preto — Unaerp School of Dentistry, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista — Unesp School of Dentistry Department of Preventive and Restorative Dentistry, SP-
Descrição: dc.descriptionNorthwestern University Feinberg School of Medicine Ann and Robert Lurie Children’s Hospital-
Descrição: dc.descriptionUniversidade Estadual Paulista — Unesp School of Dentistry Department of Preventive and Restorative Dentistry, SP-
Descrição: dc.descriptionFAPESP: #2018/17909-5-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Oral Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCaseins-
Palavras-chave: dc.subjectDental Enamel-
Palavras-chave: dc.subjectFluorides-
Palavras-chave: dc.subjectHardness-
Palavras-chave: dc.subjectPhosphates-
Título: dc.titleEffect of treatment with phosphate, casein phosphopeptide and fluoride on the remineralization: in vitro study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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