Hybrid crystalline bioparticles with nanochannels encapsulating acemannan from Aloe vera: Structure and interaction with lipid membranes

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorMax Planck Institute of Colloids and Interfaces-
Autor(es): dc.creatorMadrid, Rafael R.M.-
Autor(es): dc.creatorMathews, Patrick D.-
Autor(es): dc.creatorPramanik, Shreya-
Autor(es): dc.creatorMangiarotti, Agustín-
Autor(es): dc.creatorFernandes, Rodrigo-
Autor(es): dc.creatorItri, Rosangela-
Autor(es): dc.creatorDimova, Rumiana-
Autor(es): dc.creatorMertins, Omar-
Data de aceite: dc.date.accessioned2025-08-21T19:35:41Z-
Data de disponibilização: dc.date.available2025-08-21T19:35:41Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jcis.2024.06.073-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307352-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307352-
Descrição: dc.descriptionSmart nanocarrier-based bioactive delivery systems are a current focus in nanomedicine for allowing and boosting diverse disease treatments. In this context, the design of hybrid lipid-polymer particles can provide structure-sensitive features for tailored, triggered, and stimuli-responsive devices. In this work, we introduce hybrid cubosomes that have been surface-modified with a complex of chitosan-N-arginine and alginate, making them pH-responsive. We achieved high-efficiency encapsulation of acemannan, a bioactive polysaccharide from Aloe vera, within the nanochannels of the bioparticle crystalline structure and demonstrated its controlled release under pH conditions mimicking the gastric and intestinal environments. Furthermore, an acemannan-induced phase transition from Im3m cubic symmetry to inverse hexagonal HII phase enhances the bioactive delivery by compressing the lattice spacing of the cubosome water nanochannels, facilitating the expulsion of the encapsulated solution. We also explored the bioparticle interaction with membranes of varying curvatures, revealing thermodynamically driven affinity towards high-curvature lipid membranes and inducing morphological transformations in giant unilamellar vesicles. These findings underscore the potential of these structure-responsive, membrane-active smart bioparticles for applications such as pH-triggered drug delivery platforms for the gastrointestinal tract, and as modulators and promoters of cellular internalization.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionLaboratório Nacional de Nanotecnologia-
Descrição: dc.descriptionThe Ministry of Economic Affairs and Employment-
Descrição: dc.descriptionCentro Nacional de Pesquisa em Energia e Materiais-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLaboratory of Nano Bio Materials (LNBM) Department of Biophysics Paulista Medical School Federal University of Sao Paulo-
Descrição: dc.descriptionInstitute of Biosciences Sao Paulo State University-
Descrição: dc.descriptionMax Planck Institute of Colloids and Interfaces, Science Park Golm-
Descrição: dc.descriptionApplied Physics Department Institute of Physics University of Sao Paulo-
Descrição: dc.descriptionInstitute of Biosciences Sao Paulo State University-
Descrição: dc.descriptionCentro Nacional de Pesquisa em Energia e Materiais: 20230450-
Descrição: dc.descriptionFAPESP: 21/00971-2-
Descrição: dc.descriptionFAPESP: 22/12376-4-
Formato: dc.format373-385-
Idioma: dc.languageen-
Relação: dc.relationJournal of Colloid and Interface Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiopolymers complex-coacervates-
Palavras-chave: dc.subjectCell uptake-
Palavras-chave: dc.subjectCubosome-lipid membrane interaction-
Palavras-chave: dc.subjectLiquid crystalline phase transition-
Palavras-chave: dc.subjectSmart nanoparticle-
Palavras-chave: dc.subjectTriggered drug delivery-
Título: dc.titleHybrid crystalline bioparticles with nanochannels encapsulating acemannan from Aloe vera: Structure and interaction with lipid membranes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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