Incorporation of oligo(β-pinene) in poly(vinyl alcohol)-chitosan scaffolds: a strategy to improving biocompatibility

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorRodrigues, Plínio Ribeiro-
Autor(es): dc.creatorde Castro, Karine Cappuccio-
Autor(es): dc.creatorVicente, Cristina Pontes-
Autor(es): dc.creatorMei, Lucia Helena Innocentini-
Autor(es): dc.creatorVieira, Roniérik Pioli-
Data de aceite: dc.date.accessioned2025-08-21T19:28:03Z-
Data de disponibilização: dc.date.available2025-08-21T19:28:03Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00289-023-04942-y-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307241-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307241-
Descrição: dc.descriptionBioactive compounds blended with synthetic polymers constitute an effective alternative for tailored materials design in advanced applications. Biological functionalities are easily incorporated, and the materials’ overall performance can be improved using this technique. The present work introduces the production and characterization of electrospun scaffolds comprised poly(vinyl alcohol), chitosan, and oligo(β-pinene) with potential for tissue engineering. Oligo(β-pinene) presents many biological functionalities of interest, especially cytoprotective activity. The scaffolds’ structure, processing, properties, and performance relationships were evaluated. The materials presented an average fiber diameter of 159 nm, which was increased with the oligo(β-pinene) addition in the polymer matrix. There was an overall trend of crystallinity decrease (from 21.02 to 6.4%) with the incorporation of the oligomer. The polymers’ ∆Hm and Tm increased from 28.43 to 35.51 J g−1 and from 190.54 to 194.10 °C, respectively, with the addition of oligo(β-pinene). The presence of a few fiber defects appeared upon oligomer inclusion. However, the overall thermal performance of the scaffolds improved with the increase in oligo(β-pinene) content on the nanofibers. Essays of cell proliferation revealed significant benefits from oligo(β-pinene) inclusion on the blends tested. Biocompatibility improvement of up to 21.5% was noted compared to the control. Thus, incorporating oligo(β-pinene) in poly(vinyl alcohol)-chitosan electrospun nanofibers constitutes a renewable option to enhance the scaffolds’ properties and biocompatibility.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Bioprocesses and Materials Engineering School of Chemical Engineering University of Campinas, SP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biology University of Campinas, SP-
Descrição: dc.descriptionDepartment of Bioprocess and Biotechnology School of Agriculture Sao Paulo State University-
Descrição: dc.descriptionDepartment of Bioprocess and Biotechnology School of Agriculture Sao Paulo State University-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionCNPq: 142521/2018-3-
Descrição: dc.descriptionFAPESP: 18/02508-5-
Descrição: dc.descriptionCNPq: 403595/2021-5-
Formato: dc.format4935-4952-
Idioma: dc.languageen-
Relação: dc.relationPolymer Bulletin-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiopolymer-
Palavras-chave: dc.subjectBlends-
Palavras-chave: dc.subjectElectrospinning-
Palavras-chave: dc.subjectNanofibers-
Palavras-chave: dc.subjectO-ATRP-
Palavras-chave: dc.subjectTissue engineering-
Título: dc.titleIncorporation of oligo(β-pinene) in poly(vinyl alcohol)-chitosan scaffolds: a strategy to improving biocompatibility-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.