Titanium dioxide nanotubes incorporated into conventional glass ionomer cement alter the biological behavior of pre-odontoblastic cells

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFaculdade São Leopoldo Mandic (SLMANDIC)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversity of Kentucky-
Autor(es): dc.contributorScience & Research Institute-
Autor(es): dc.contributorSchool of Dentistry-
Autor(es): dc.creatorMeyer, Maria Davoli-
Autor(es): dc.creatorCoelho, Rogério Meneses Ibiapina-
Autor(es): dc.creatorRangel-Coelho, João Pedro-
Autor(es): dc.creatorCosta, Bruna Carolina-
Autor(es): dc.creatorTeixeira, Lucas Novaes-
Autor(es): dc.creatorMartinez, Elizabeth Ferreira-
Autor(es): dc.creatorCasarin, Renato Corrêa Viana-
Autor(es): dc.creatorSantamaria, Mauro Pedrine-
Autor(es): dc.creatorFrança, Fabiana Mantovani Gomes-
Autor(es): dc.creatorNociti-Jr, Francisco Humberto-
Autor(es): dc.creatorLisboa-Filho, Paulo Noronha-
Autor(es): dc.creatorKantovitz, Kamila Rosamilia-
Data de aceite: dc.date.accessioned2025-08-21T15:41:22Z-
Data de disponibilização: dc.date.available2025-08-21T15:41:22Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.colsurfb.2024.114389-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307236-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307236-
Descrição: dc.descriptionThe objective was to address the repercussion of adding titanium dioxide nanotubes (TiO2-nt) into high-viscosity conventional glass ionomer cement (GIC) on the biological properties of pre-odontoblastic cells (MDPC-23) challenged by lipopolysaccharides (LPS - 2 μg/mL). TiO2-nt was added to Ketac Molar EasyMix at 3, 5, 7 %, whereas unblended GIC served as control. Analyses included proliferation (n=6; 24, 48, 72 h), metabolism (MTT; n=6; 24, 48, 72 h); morphology laser microscopy (n=3; 24, 48, 72 h); proteome assessments IL-1β, IL-6, IL-10, VEGF, TNF-α (n=3; 12, 18 h); mRNA levels (RT-PCR) of Il-1β, Il-6, Il-10, VEGF, TNF-α (n=3; 12, 18 h) and DSPP (n=3; 24, 72, 120 h). Data analysis included Shapiro-Wilk, Levene, and generalized linear models (α=0.05). Results demonstrated that cell proliferation increased over time for all groups, and was not impacted by TiO2-nt (p>0.05). GIC groups displayed lower MTT values compared to cells cultured without GIC discs (p=0.019); disregarding the presence of TiO2. Remarkably, TiO2-nt reversed the effect of GIC, reducing the levels of selected biomarkers. LPS treatment modified the expression of the immune-inflammatory markers by MDPC-23 cells (p<0.0001). Morphological analysis did not reveal distinctions for any of the studied. TiO2-nt modulated immune-inflammatory and dentin marker expression by MDPC-23 cells cultured on conventional GIC discs, and did not affect cell morphology/viability, regardless LPS exposure. In conclusion, TiO2-nt may become a reliable clinical strategy to encourage pulp tissue repair.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionFaculdade São Leopoldo Mandic (SLMANDIC), Rua José Rocha Junqueira 13, Swift, SP-
Descrição: dc.descriptionSchool of Science State University Júlio de Mesquita (UNESP), Av. Engenheiro Luís Edmundo Carrijo Coube 2085, SP-
Descrição: dc.descriptionPiracicaba Dental School State University of Campinas (FOP-UNICAMP), Av. Limeira 901, Areião, SP-
Descrição: dc.descriptionCollege of Dentistry University of Kentucky, 1095 Veterans Dr.-
Descrição: dc.descriptionAmerican Dental Association Science & Research Institute, 100 Bureau Dr.-
Descrição: dc.descriptionDepartment of Comprehensive Dentistry University of Maryland School of Dentistry, 650 W Baltimore St.-
Descrição: dc.descriptionSchool of Science State University Júlio de Mesquita (UNESP), Av. Engenheiro Luís Edmundo Carrijo Coube 2085, SP-
Descrição: dc.descriptionFAPESP: 2019/14078-8-
Descrição: dc.descriptionFAPESP: 2020/15865-0-
Idioma: dc.languageen-
Relação: dc.relationColloids and Surfaces B: Biointerfaces-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDental Restoration-
Palavras-chave: dc.subjectGlass Ionomer Cements-
Palavras-chave: dc.subjectOdontoblasts-
Palavras-chave: dc.subjectPulp-
Título: dc.titleTitanium dioxide nanotubes incorporated into conventional glass ionomer cement alter the biological behavior of pre-odontoblastic cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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