CTX-M-producing Escherichia coli ST602 carrying a wide resistome in South American wild birds: Another pandemic clone of One Health concern

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorOne Health Brazilian Resistance Project (OneBR)-
Autor(es): dc.contributorUniversidad de Concepción-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal Institute of Espírito Santo-
Autor(es): dc.contributorUniversity of Agriculture-
Autor(es): dc.creatorDalazen, Gislaine-
Autor(es): dc.creatorFuentes-Castillo, Danny-
Autor(es): dc.creatorPedroso, Luiz G.-
Autor(es): dc.creatorFontana, Herrison-
Autor(es): dc.creatorSano, Elder-
Autor(es): dc.creatorCardoso, Brenda-
Autor(es): dc.creatorEsposito, Fernanda-
Autor(es): dc.creatorMoura, Quezia-
Autor(es): dc.creatorMatinata, Bianca S.-
Autor(es): dc.creatorSilveira, Luiz F.-
Autor(es): dc.creatorMohsin, Mashkoor-
Autor(es): dc.creatorMatushima, Eliana R.-
Autor(es): dc.creatorLincopan, Nilton-
Data de aceite: dc.date.accessioned2025-08-21T21:58:23Z-
Data de disponibilização: dc.date.available2025-08-21T21:58:23Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.onehlt.2023.100586-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307231-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307231-
Descrição: dc.descriptionWild birds have emerged as novel reservoirs and potential spreaders of antibiotic-resistant priority pathogens, being proposed as sentinels of anthropogenic activities related to the use of antimicrobial compounds. The aim of this study was to investigate the occurrence and genomic features of extended-spectrum β-lactamase (ESBL)-producing bacteria in wild birds in South America. In this regard, we have identified two ESBL (CTX-M-55 and CTX-M-65)-positive Escherichia coli (UNB7 and GP188 strains) colonizing Creamy-bellied Thrush (Turdus amaurochalinus) and Variable Hawk (Geranoaetus polyosoma) inhabiting synanthropic and wildlife environments from Brazil and Chile, respectively. Whole-genome sequence (WGS) analysis revealed that E. coli UNB7 and GP188 belonged to the globally disseminated clone ST602, carrying a wide resistome against antibiotics (β-lactams), heavy metals (arsenic, copper, mercury), disinfectants (quaternary ammonium compounds), and pesticides (glyphosate). Additionally, E. coli UNB7 and GP188 strains harbored virulence genes encoding hemolysin E, type II and III secretion systems, increased serum survival, adhesins and siderophores. SNP-based phylogenomic analysis, using an international genome database, revealed genomic relatedness (19–363 SNP differences) of GP188 with livestock and poultry strains, and genomic relatedness (61–318 differences) of UNB7 with environmental, human and livestock strains (Table S1), whereas phylogeographical analysis confirmed successful expansion of ST602 as a global clone of One Health concern. In summary, our results support that ESBL-producing E. coli ST602 harboring a wide resistome and virulome have begun colonizing wild birds in South America, highlighting a potential new reservoir of critical priority pathogens.-
Descrição: dc.descriptionBill and Melinda Gates Foundation-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionComisión Nacional de Investigación Científica y Tecnológica-
Descrição: dc.descriptionLaboratory of Wildlife Comparative Pathology Department of Pathology School of Veterinary Medicine and Animal Sciences University of São Paulo-
Descrição: dc.descriptionOne Health Brazilian Resistance Project (OneBR)-
Descrição: dc.descriptionDepartamento de Patología y Medicina Preventiva Facultad de Ciencias Veterinarias Universidad de Concepción-
Descrição: dc.descriptionLaboratory of Acarology Department of Zoology São Paulo State University, Rio Claro-
Descrição: dc.descriptionDepartment of Clinical Analysis Faculty of Pharmacy University of São Paulo-
Descrição: dc.descriptionDepartment of Microbiology Institute of Biomedical Sciences University of São Paulo-
Descrição: dc.descriptionFederal Institute of Espírito Santo-
Descrição: dc.descriptionZoology Museum of the University of São Paulo University of São Paulo-
Descrição: dc.descriptionInstitute of Microbiology University of Agriculture-
Descrição: dc.descriptionLaboratory of Acarology Department of Zoology São Paulo State University, Rio Claro-
Descrição: dc.descriptionFAPESP: 2019/15578-4-
Descrição: dc.descriptionFAPESP: 2020/08224-9-
Descrição: dc.descriptionCNPq: 314336/2021-4-
Descrição: dc.descriptionCAPES: 88882.333054/2019-01-
Descrição: dc.descriptionCNPq: 88882.333054/2019-01-
Descrição: dc.descriptionCAPES: 88882.333521/2019-01-
Descrição: dc.descriptionCAPES: 88887.506496/2020-00-
Descrição: dc.descriptionComisión Nacional de Investigación Científica y Tecnológica: CONICYT BCH 72170436-
Descrição: dc.descriptionBill and Melinda Gates Foundation: OPP1193112-
Idioma: dc.languageen-
Relação: dc.relationOne Health-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntimicrobial resistance-
Palavras-chave: dc.subjectESBL-
Palavras-chave: dc.subjectGenomic surveillance-
Palavras-chave: dc.subjectHigh-risk clone-
Palavras-chave: dc.subjectWHO priority pathogens-
Palavras-chave: dc.subjectWildlife-
Título: dc.titleCTX-M-producing Escherichia coli ST602 carrying a wide resistome in South American wild birds: Another pandemic clone of One Health concern-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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