Chemotherapeutic Mechanism of Action of the Synthetic Resorcinolic Methyl 3,5-dimethoxy-2-octanoylbenzoate

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Autor(es): dc.contributorFederal University of Mato Grosso do Sul-
Autor(es): dc.contributorFederal University of Grande Dourados-
Autor(es): dc.contributorNorth Dakota State University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCorrea, Willian Ayala-
Autor(es): dc.creatordas Neves, Silvia Cordeiro-
Autor(es): dc.creatorOliveira, Rodrigo Juliano-
Autor(es): dc.creatorKassuya, Cândida A.-
Autor(es): dc.creatorNavarro, Stephanie D.-
Autor(es): dc.creatorFaustino Martins, Allana Cristina-
Autor(es): dc.creatorSaroja, Baby-
Autor(es): dc.creatorMitsuyasu, Barbara-
Autor(es): dc.creatorOstaciana Maia Freitas da Silveira, Ingridhy-
Autor(es): dc.creatorVitor, Neimar-
Autor(es): dc.creatorCoelho, Henrique Rodrigues Scherer-
Autor(es): dc.creatorVilela, Marcelo L. B.-
Autor(es): dc.creatordo Nascimento, Valter A.-
Autor(es): dc.creatorde Lima, Dênis P.-
Autor(es): dc.creatorBeatriz, Adilson-
Autor(es): dc.creatorda Silva Gomes, Roberto-
Data de aceite: dc.date.accessioned2025-08-21T16:10:48Z-
Data de disponibilização: dc.date.available2025-08-21T16:10:48Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-02-19-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acs.chemrestox.3c00269-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307218-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307218-
Descrição: dc.descriptionResorcinolic lipids are described as potential examples of selective chemotherapeutic adjuvants that can enhance the effects of cyclophosphamide (CYC) while promoting cell death without causing DNA damage. Therefore, the current study attempted to describe how the resorcinolic lipid methyl 3,5-dimethoxy-2-octanoylbenzoate (AMS35BB) interacted with DNA (DNA docking) and how this compound affected genetic toxicology models and other biological characteristics when combined with CYC. We observed that AMS35BB, used alone (7.5 and 10 mg/kg), increases the frequency of genomic damage (comet assay) but not chromosomal damage (micronuclei assay), lowers phagocytosis, and promotes cell death in Swiss male mice. When used in association with CYC, AMS35BB can reduce the risk of genomic damage by up to 33.8% as well as chromosomal damage, splenic phagocytosis, cell death, and lymphocyte frequency. Molecular docking showed that AMS35BB had a higher affinity than the active metabolite of CYC for binding to the DNA double helix major groove. As a result, AMS35BB has the potential to be both an adjuvant when used in association with CYC and a therapeutic candidate for the development of a selective chemotherapeutic drug.-
Descrição: dc.descriptionInstitute of Chemistry Federal University of Mato Grosso do Sul, Mato Grosso do Sul-
Descrição: dc.descriptionStem Cell Cell Therapy and Toxicological Genetics Research Centre (CeTroGen) Medical School Federal University of Mato Grosso do Sul, Mato Grosso do Sul-
Descrição: dc.descriptionGraduate Program in Health and Development in the Midwest Region Medical School Federal University of Mato Grosso do Sul, Mato Grosso do Sul-
Descrição: dc.descriptionSchool of Health Sciences Federal University of Grande Dourados, Mato Grosso do Sul-
Descrição: dc.descriptionDepartment of Pharmaceutical Sciences North Dakota State University-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences Sao Paulo State University (UNESP), Sao Paulo-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences Sao Paulo State University (UNESP), Sao Paulo-
Formato: dc.format259-273-
Idioma: dc.languageen-
Relação: dc.relationChemical Research in Toxicology-
???dc.source???: dc.sourceScopus-
Título: dc.titleChemotherapeutic Mechanism of Action of the Synthetic Resorcinolic Methyl 3,5-dimethoxy-2-octanoylbenzoate-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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